A2VDN6

PR
Gene name
SF3A1
Protein name
Splicing factor 3A subunit 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:504381
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

323-405 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2VDN6

Entry ID Method Resolution Chain Position Source
AF-A2VDN6-F1 Predicted AlphaFoldDB

239 variants for A2VDN6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs438244909 9 V>G No EVA
rs456669663 9 V>L No EVA
rs476282748 10 P>S No EVA
rs432710953 15 A>P No EVA
rs465735884 16 A>D No EVA
rs453736392 21 Q>H No EVA
rs471916014 22 P>H No EVA
rs453263192 34 T>P No EVA
rs434808504 44 Y>S No EVA
rs468067706 52 I>L No EVA
rs455985180 59 F>L No EVA
rs437321283 62 R>I No EVA
rs437380518 132 V>D No EVA
rs431910408 133 Q>H No EVA
rs450511653 133 Q>K No EVA
rs464924359 134 A>G No EVA
rs446467277 135 Q>L No EVA
rs461265676 149 E>G No EVA
rs449063564 156 P>A No EVA
rs438880724 159 I>S No EVA
rs463819497 159 I>V No EVA
rs471956244 160 S>A No EVA
rs441196900 162 F>C No EVA
rs474280080 163 D>V No EVA
rs455893289 164 L>R No EVA
rs465512953 166 V>A No EVA
rs443755270 167 V>G No EVA
rs451928463 168 K>N No EVA
rs432046566 177 N>K No EVA
rs465093878 178 G>V No EVA
rs452896520 183 T>A No EVA
rs434380309 184 Q>H No EVA
rs467627464 189 E>K No EVA
rs449204577 192 N>S No EVA
rs482162186 193 Y>S No EVA
rs469957795 196 D>A No EVA
rs520407793 210 K>N No EVA
rs445063845 211 L>M No EVA
rs478331499 212 V>G No EVA
rs1117321293 242 Q>P No EVA
rs479608190 293 G>A No EVA
rs461189455 296 P>A No EVA
rs442885459 299 T>N No EVA
rs482403623 300 T>P No EVA
rs463696201 301 P>R No EVA
rs471871932 303 E>A No EVA
rs438808240 303 E>Q No EVA
rs453492251 308 I>N No EVA
rs441321015 310 I>S No EVA
rs474204314 312 E>G No EVA
rs455957526 315 E>G No EVA
rs469133332 320 S>G No EVA
rs456851734 321 E>* No EVA
rs431976949 323 V>G No EVA
rs446757212 332 E>G No EVA
rs467551602 344 S>Y No EVA
rs482349636 351 Q>H No EVA
rs467338255 352 V>A No EVA
rs438743632 354 D>G No EVA
rs463878675 354 D>H No EVA
rs464813175 362 E>Q No EVA
rs479346567 363 E>D No EVA
rs448283611 397 A>V No EVA
rs462707992 398 S>P No EVA
rs477470518 399 K>R No EVA
rs440392356 401 L>M No EVA
rs473376546 401 L>R No EVA
rs443071810 402 P>H No EVA
rs457442498 404 A>G No EVA
rs457442498 404 A>V No EVA
rs433700035 408 D>E No EVA
rs452083113 408 D>G No EVA
rs452083113 408 D>V No EVA
rs466503778 409 E>G No EVA
rs481341283 410 Y>C No EVA
rs448100179 410 Y>N No EVA
rs450671529 411 L>H No EVA
rs458770019 412 V>G No EVA
rs440534622 413 S>P No EVA
rs461286911 415 I>N No EVA
rs476061008 416 T>N No EVA
rs442837018 416 T>P No EVA
rs439105216 419 K>N No EVA
rs453413008 420 I>M No EVA
rs471806155 420 I>T No EVA
rs433638345 424 K>N No EVA
rs466700467 427 E>D No EVA
rs454413485 429 M>K No EVA
rs435992520 430 R>S No EVA
rs450808742 434 L>P No EVA
rs469211824 434 L>V No EVA
rs477344542 435 D>H No EVA
rs479926499 438 W>C No EVA
rs446695666 438 W>G No EVA
rs461459523 439 L>R No EVA
rs482262959 442 R>G No EVA
rs463636098 442 R>Q No EVA
rs441424535 443 D>E No EVA
rs459746893 443 D>G No EVA
rs471939714 443 D>H No EVA
rs436124655 448 E>* No EVA
rs475393854 450 Q>E No EVA
rs456953438 451 S>C No EVA
rs432229023 456 Y>* No EVA
rs465277081 457 A>T No EVA
rs446615287 458 P>T No EVA
rs434592581 459 G>C No EVA
rs457742154 491 E>G No EVA
rs472683735 499 K>N No EVA
rs439383372 499 K>T No EVA
rs136649990 503 D>A No EVA
rs442080233 506 S>A No EVA
rs475151654 508 S>T No EVA
rs456501873 511 R>G No EVA
rs438009523 511 R>P No EVA
rs471251180 512 T>A No EVA
rs452818623 514 Q>H No EVA
rs434322088 521 T>P No EVA
rs467115469 522 L>R No EVA
rs455158241 527 E>K No EVA
rs468125814 581 A>P No EVA
rs449541617 581 A>V No EVA
rs467849509 587 R>G No EVA
rs449159310 587 R>P No EVA
rs470056639 588 T>P No EVA
rs445483824 589 T>P No EVA
rs459913565 590 V>A No EVA
rs459913565 590 V>G No EVA
rs441412053 591 V>L No EVA
rs442580760 592 S>C No EVA
rs461052816 592 S>P No EVA
rs442580760 592 S>Y No EVA
rs475393688 593 A>E No EVA
rs456953483 594 V>G No EVA
rs438667520 595 P>L No EVA
rs453038586 596 V>D No EVA
rs471696782 596 V>F No EVA
rs453038586 596 V>G No EVA
rs467445971 597 M>I No EVA
rs455671854 599 R>G No EVA
rs437286763 599 R>L No EVA
rs445216759 600 P>A No EVA
rs478524174 601 P>L No EVA
rs466427353 602 M>R No EVA
rs447814236 603 A>P No EVA
rs448975867 604 S>F No EVA
rs462388531 604 S>P No EVA
rs448975867 604 S>Y No EVA
rs463324425 606 V>G No EVA
rs471669836 611 G>A No EVA
rs455410551 617 M>I No EVA
rs473782643 617 M>T No EVA
rs476533812 621 I>T No EVA
rs433183352 627 N>T No EVA
rs466225867 628 V>A No EVA
rs447880252 629 V>G No EVA
rs450328281 638 I>S No EVA
rs481871115 639 M>T No EVA
rs444971967 641 P>T No EVA
rs441077637 646 M>V No EVA
rs473604214 651 A>G No EVA
rs473921585 651 A>S No EVA
rs473921585 651 A>T No EVA
rs473604214 651 A>V No EVA
rs455005912 653 V>G No EVA
rs455927924 655 A>D No EVA
rs474529883 655 A>P No EVA
rs437585652 656 P>Q No EVA
rs445904866 657 P>S No EVA
rs445904866 657 P>T No EVA
rs448315346 658 V>A No EVA
rs448315346 658 V>G No EVA
rs466737755 658 V>L No EVA
rs463063231 659 A>E No EVA
rs463063231 659 A>G No EVA
rs477433574 660 P>A No EVA
rs458907993 660 P>L No EVA
rs477433574 660 P>T No EVA
rs461350807 661 V>A No EVA
rs473518859 661 V>F No EVA
rs461350807 661 V>G No EVA
rs442980764 662 P>L No EVA
rs437715116 663 A>G No EVA
rs456074374 663 A>P No EVA
rs456074374 663 A>S No EVA
rs452027301 664 P>Q No EVA
rs466874491 665 A>P No EVA
rs466874491 665 A>S No EVA
rs469216581 667 M>I No EVA
rs436169022 667 M>K No EVA
rs454686039 667 M>L No EVA
rs436169022 667 M>R No EVA
rs436169022 667 M>T No EVA
rs454686039 667 M>V No EVA
rs450948735 668 P>A No EVA
rs450948735 668 P>S No EVA
rs450948735 668 P>T No EVA
rs446827954 670 V>A No EVA
rs465334692 670 V>F No EVA
rs479870404 671 H>P No EVA
rs482204336 675 P>R No EVA
rs444083489 676 M>L No EVA
rs470696832 676 M>R No EVA
rs440042489 678 D>A No EVA
rs452036653 678 D>N No EVA
rs440042489 678 D>V No EVA
rs473034118 679 E>* No EVA
rs454817465 679 E>A No EVA
rs436302164 679 E>D No EVA
rs432430379 690 S>R No EVA
rs465425432 692 M>I No EVA
rs446792751 693 P>T No EVA
rs479604651 695 E>* No EVA
rs457679843 700 R>S No EVA
rs467633826 701 N>K No EVA
rs452468361 762 I>S No EVA
rs433760384 763 F>L No EVA
rs466796922 766 D>E No EVA
rs448583944 767 S>C No EVA
rs481594705 770 L>R No EVA
rs450797915 773 Y>F No EVA
rs469377019 773 Y>H No EVA
rs469377019 773 Y>N No EVA
rs477696881 775 M>L No EVA
rs459071394 776 A>D No EVA
rs461412053 780 V>A No EVA
rs441670656 781 I>T No EVA
rs474731260 783 L>R No EVA
rs452403228 791 R>G No EVA
rs433899395 791 R>K No EVA
rs454747811 792 K>* No EVA
rs454747811 792 K>E No EVA
rs436448476 792 K>N No EVA
rs454747811 792 K>Q No EVA
rs469463830 793 K>E No EVA
rs451013906 793 K>N No EVA
rs477442851 794 K>E No EVA
rs477442851 794 K>K No EVA
rs465223705 794 K>W No EVA

No associated diseases with A2VDN6

5 regional properties for A2VDN6

Type Name Position InterPro Accession
domain SWAP/Surp 50 - 103 IPR000061-1
domain SWAP/Surp 164 - 217 IPR000061-2
domain Ubiquitin-like domain 707 - 790 IPR000626
domain Splicing factor 3A subunit 1, conserved domain 233 - 472 IPR022030
domain Splicing factor 3A subunit 1, ubiquitin domain 704 - 786 IPR035563

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Nucleus speckle
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes.
U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs.
U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.
U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
U2-type prespliceosome assembly The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15459 SF3A1 Splicing factor 3A subunit 1 Homo sapiens (Human) PR
Q8K4Z5 Sf3a1 Splicing factor 3A subunit 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MPAGPVQAVP PPPPAATEPK QPTEEEASSK EDSTPSKPVV GIIYPPPEVR NIVDKTASFV
70 80 90 100 110 120
ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AAIPKVMQQQ
130 140 150 160 170 180
QQASQQQLPQ KVQAQVIQET IVPKEPPPEF EFIADPPSIS AFDLDVVKLT AQFVARNGRQ
190 200 210 220 230 240
FLTQLMQKEQ RNYQFDFLRP QHSLFNYFTK LVEQYTKILI PPKGLFTKLK KEAENPREVL
250 260 270 280 290 300
DQVCYRVEWA KFQERERKKE EEEKEKERVA YAQIDWHDFV VVETVDFQPN EQGNFPPPTT
310 320 330 340 350 360
PEELGARILI QERYEKFGES EEVEMEVESD EEDEKQEKAE EPPSQLDQDT QVQDMDEGSD
370 380 390 400 410 420
DEEEGQKVPP PPETPMPPPL PPTPDQVIVR KDYDPKASKP LPPAPAPDEY LVSPITGEKI
430 440 450 460 470 480
PASKMQEHMR IGLLDPRWLE QRDRSIREKQ SDDEVYAPGL DIESSLKQLA ERRTDIFGVE
490 500 510 520 530 540
ETAIGKKIGE EEIQKPEEKV TWDGHSGSMA RTQQAAQANI TLQEQIEAIH KAKGLVPEDD
550 560 570 580 590 600
TKEKIGPSKP NEIPQQPPPP SSATNIPSSA PPITSVPRPP AMPPPVRTTV VSAVPVMPRP
610 620 630 640 650 660
PMASVVRLPP GSVIAPMPPI IHAPRINVVP MPPSAPPIMA PRPPPMIVPT AFVPAPPVAP
670 680 690 700 710 720
VPAPAPMPPV HPPPPMEDEP ASKKLKTEDS LMPEEEFLRR NKGPVSIKVQ VPNMQDKTEW
730 740 750 760 770 780
KLNGQVLVFT LPLTDQVSVI KVKIHEATGM PAGKQKLQYE GIFIKDSNSL AYYNMANGAV
790
IHLALKERGG RKK