A2TJ54
Gene name |
CLN5 |
Protein name |
Ceroid-lipofuscinosis neuronal protein 5 |
Names |
Protein CLN5 |
Species |
Ovis aries (Sheep) |
KEGG Pathway |
oas:100034668 |
EC number |
3.1.2.22: Thiolester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2TJ54
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2TJ54-F1 | Predicted | AlphaFoldDB |
No variants for A2TJ54
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2TJ54 | |||||
1 associated diseases with A2TJ54
Without disease ID
No regional properties for A2TJ54
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2TJ54 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.2.22 | Thiolester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose binding | Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| glycosylation | The covalent attachment and further modification of carbohydrate residues to a substrate molecule. |
| positive regulation of GTP binding | Any process that activates or increases the frequency, rate or extent of GTP binding. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
| signal peptide processing | The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAQAGGAGAG | AWGRRGAGAG | AGPERAPWRW | APALLWLAAA | TAAAAAAGDP | SRRQWPVPYK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFSFRPEPDP | YCQAKYTFCP | TGSPIPVMKD | DDVIEVFRLQ | APVWEFKYGD | LLGHLKIMHD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AIGFRSTLTE | KNYTMEWYEL | FQLGNCTFPH | LRPEMNAPFW | CNQGAACFFE | GIDDNHWKEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTLVLVATIS | GGMFNKMAKW | VKQDNETGIY | YETWTVQASP | KKEAEKWFES | YDCSKFVLRT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YEKLAELGAD | FKKIETNYTR | IFLYSGEPTY | LGNETSVFGP | TGNKTLALAI | KKFYYPFKPH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSTKEFLLSL | LQIFDAVVIH | REFYLFYNFE | YWFLPMKSPF | IKITYEEIPL | PNRKNRTLSG |
| L |