A2SIR4
Gene name |
dnaK |
Protein name |
Chaperone protein DnaK |
Names |
HSP70, Heat shock 70 kDa protein, Heat shock protein 70 |
Species |
Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) |
KEGG Pathway |
mpt:Mpe_A2498 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2SIR4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2SIR4-F1 | Predicted | AlphaFoldDB |
No variants for A2SIR4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2SIR4 | |||||
No associated diseases with A2SIR4
3 regional properties for A2SIR4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 7 - 14 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 166 - 179 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 307 - 321 | IPR018181-3 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent protein folding chaperone | Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. |
| unfolded protein binding | Binding to an unfolded protein. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKIIGIDLG | TTNSCVAIME | GNTTKVIENS | EGARTTPSII | AYQEDGEVLV | GASAKRQAVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NPRNTLYAVK | RLIGRKFTEK | EVQKDIDLMP | YTIAAAENGD | AWVEVRGNKL | APPQVSAEVL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKMKKTAEDY | LGETVTEAVI | TVPAYFNDAQ | RQATKDAGRI | AGLDVKRIIN | EPTAAALAFG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDKHNDGKGG | DRKIAVYDLG | GGTFDISIIE | IADVDGEMQF | EVLSTNGDTF | LGGEDFDQRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IDYIIAEFKK | EQGVDLSKDV | LALQRLKEAA | EKAKIELSNS | TQTDINLPYV | TADASGPKHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NIKLTRAKLE | ALVEELIERT | IAPCRTAIKD | AGVSTSQIND | VILVGGMTRM | PKVQEKVKEF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FGQEPRKDVN | PDEAVAVGAA | IQGQVLAGDR | KDVLLLDVTP | LSLGIETLGG | VMTKMITKNT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIPTKFAQTF | STADDNQPAV | TIKVFQGERE | LASGNKMLGE | FNLEGIAPAP | RGMPQIEVSF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DIDANGILHV | GAKDKGTGKE | NKITIKANSG | LSEEEIQKMV | KDAELNAAED | KKKLELVQAR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NQADAMVHSV | KKSLAEHGDK | LDAGEKEKIE | SALKDAETAL | KGEDKAEIEA | KTEALMSASQ |
| 610 | 620 | 630 | 640 | 650 | |
| KLGEKVYADM | QAAQAAAGAA | AGGGEAPAAE | ATASKPADDN | VVDAEFKEVK | DQK |