A2RUM7
Gene name |
RPL5 (hCG_2028912) |
Protein name |
(Ribosomal protein L5 , mRNA) |
Names |
Ribosomal protein L5, isoform CRA_c, cDNA, FLJ95579, Homo sapiens ribosomal protein L5 (RPL5) |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6125 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2RUM7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2RUM7-F1 | Predicted | AlphaFoldDB |
No variants for A2RUM7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2RUM7 | |||||
No associated diseases with A2RUM7
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5S rRNA binding | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGFVKVVKNK | AYFKRYQVKF | RRRREGKTDY | YARKRLVIQD | KNKYNTPKYR | MIVRVTNRDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ICQIAYARIE | GDMIVCAAYA | HELPKYGVKV | GLTNYAAAYC | TGLLLARRLL | NRFGMDKIYE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GQVEVTGDEY | NVESIDGQPG | AFTCYLDAGL | ARTTTGNKVF | GALKGAVDGG | LSIPHSTKRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGYDSESKEF | NAEVHRKHIM | GQNVADYMRY | LMEEDEDAYK | KQFSQYIKNS | VTPDMMEEMY |
| 250 | 260 | 270 | 280 | 290 | |
| KKAHAAIREN | PVYEKKPKKE | VKKKRWNRPK | MSLAQKKDRV | AQKKASFLRA | QERAAES |