A2RML9

PR
Gene name
rpoB
Protein name
DNA-directed RNA polymerase subunit beta
Names
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta
Species
Lactococcus lactis subsp cremoris (strain MG1363)
KEGG Pathway
llm:llmg_1982
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

765-837 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2RML9

Entry ID Method Resolution Chain Position Source
AF-A2RML9-F1 Predicted AlphaFoldDB

No variants for A2RML9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2RML9

No associated diseases with A2RML9

8 regional properties for A2RML9

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 679 - 1065 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 918 - 930 IPR007121
domain RNA polymerase Rpb2, domain 7 1067 - 1141 IPR007641
domain RNA polymerase Rpb2, domain 2 140 - 292 IPR007642-1
domain RNA polymerase Rpb2, domain 2 368 - 414 IPR007642-2
domain RNA polymerase, beta subunit, protrusion 28 - 460 IPR007644
domain RNA polymerase Rpb2, domain 3 473 - 538 IPR007645
domain DNA-directed RNA polymerase, beta subunit, external 1 domain 551 - 618 IPR019462

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGHDVKYGK HRTRRSFSRI KEVIGLPNLI EVQTLSYKNF LDEGLANVFK EMFPIDNFAG
70 80 90 100 110 120
TMELEFVGYE MKTPKYTVEE ARAHDANYSA PIYVTFRLVN KETGELKTQE VFFGDFPLMT
130 140 150 160 170 180
EMGTFINNGS ERLIVSQLVR SPGSYFHLKT DKNGLESFGH TTIPNRGAWF ELDTDAKGIG
190 200 210 220 230 240
YVRIDRTRKL TFTTMLRALG FGSDDEILEL LGETQLLTDT IAKDVHKNPA DTRVEEALKD
250 260 270 280 290 300
IYDRLRPGEP KTADSSRGLL VARFFDPKRY DFAPVGRYKF NKKLALKNRL LGLTLAEPIV
310 320 330 340 350 360
DPETGEILVN TDTLVTRDVL DLIEPLLDNG LGNFVVEPSD DAVIPEPITL QSIKVYSPKD
370 380 390 400 410 420
SERVVTLLSN GNPDSECRVL TPADVISNIS YWLGLAEGIG KVDDIDHLGN RRIRSVGELL
430 440 450 460 470 480
QNQVRIGLSR MERVIRERMS SSENENITPQ GLINIRPVTA SIKEFFGSSQ LSQFMDQHNP
490 500 510 520 530 540
LSELSHKRRF SALGPGGISR DRASYEVRDV HYTHYGRMCP IETPEGPNIG LINNLSSYAK
550 560 570 580 590 600
VNEYGFIMSP YRRVDRVNGI VTDEVEYLTA DEEDNYTVAQ ANSPLTDDSR FANETVMARH
610 620 630 640 650 660
TGNNIEVEAS TADYMDVSPK QVIAVAAACI PFLENDDSNR ALMGANMQRQ AVPLIDPHAP
670 680 690 700 710 720
WIGTGMEHQT ARDSGAALLA KHAGVVEYVD GNEIRVRRTS GELDIYNITK YRRSNSGTSY
730 740 750 760 770 780
NQRPLARLGE KVEKNDIIAD GPSMENGEMA LGQNPLVAYM TWEGYNFEDA VIMSERLIKD
790 800 810 820 830 840
DVYTSIAIEE YESETRDTKL GPEEITREIP NVGDEALKNL DESGIIRIGA EVKDGDLLVG
850 860 870 880 890 900
KVTPKGETDP TPEERLLRAI FGEKAREVRD TSLRVPHGGG GIVHDVRVFT RENGDELPSG
910 920 930 940 950 960
VNKLVRVFIA QKRKIHVGDK MAGRHGNKGV VSNIVPVEDM PYLPDGTPID IMLNPLGVPS
970 980 990 1000 1010 1020
RMNIGQVMEL HLGMAARTLG IHIATPVFDG ASDEDIWDTV KEAGMAADAK TVLYDGRTGE
1030 1040 1050 1060 1070 1080
PFDNRISVGV MYMIKLHHMV DDKLHARSVG PYSLVTQQPL GGKAQFGGQR FGEMEVWALE
1090 1100 1110 1120 1130 1140
AYGAANVLQE ILTYKSDDVI GRTRAYEAIV KGERIPKPGL PESFRVLVKE LQSLGLDMKV
1150 1160 1170 1180 1190
LDADRNVLDL RELDEDEVMT RPDNTEITPE MLEAQEAIVA QAEAEEEALI NADIEK