A2RJM8

PR
Gene name
proA
Protein name
Gamma-glutamyl phosphate reductase
Names
GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, GSA dehydrogenase
Species
Lactococcus lactis subsp cremoris (strain MG1363)
KEGG Pathway
llm:llmg_0886
EC number
1.2.1.41: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2RJM8

Entry ID Method Resolution Chain Position Source
AF-A2RJM8-F1 Predicted AlphaFoldDB

No variants for A2RJM8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2RJM8

No associated diseases with A2RJM8

4 regional properties for A2RJM8

Type Name Position InterPro Accession
domain GPR domain 1 - 413 IPR000965
domain Aldehyde dehydrogenase domain 10 - 280 IPR015590-1
domain Aldehyde dehydrogenase domain 314 - 376 IPR015590-2
conserved_site Gamma-glutamyl phosphate reductase GPR, conserved site 320 - 341 IPR020593

Functions

Description
EC Number 1.2.1.41 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

1 GO annotations of biological process

Name Definition
L-proline biosynthetic process The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEELGLKVK TASKEAAKLS TAEKNTFLQK LADSLVENTD RIISENAKDL AKAKGHGISE
70 80 90 100 110 120
IMVDRLRLTA QRISDMATGL RQVAELPDPI GQVLQGFTNL DGLKIVQKRV PLGTVGMIFE
130 140 150 160 170 180
SRPNVTIDAF SLCFKTGNSV LLRGGSDAIY SNMVLVEIIK ENLLSAKITD GVVELLSDTS
190 200 210 220 230 240
HAEAEKMMQA DKFLDVLIPR GSARLINRVK EKATVPVIET GVGNCTIFVD ESADLDMATR
250 260 270 280 290 300
IVINAKTQRP SVCNAAESLV VHAKIADEFL PKLQNEINKV HEVEFRADER SLKALSAGIP
310 320 330 340 350 360
ATDEDFGMEF LDYILSVKTV DNLDEAIEHI NTYSSRHSES IVTHDYFNAQ KFQDEIDAAA
370 380 390 400 410
VYVNASTRFT DGFVFGLGAE IGISTQKLHA RGPMGLEALT STKYLIDGCG QIR