A2QY22

PR
Gene name
chl1 (An11g11040)
Protein name
ATP-dependent DNA helicase chl1
Names
Chromosome loss protein 1
Species
Aspergillus niger (strain CBS 51388 / FGSC A1513)
KEGG Pathway
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-330 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2QY22

Entry ID Method Resolution Chain Position Source
AF-A2QY22-F1 Predicted AlphaFoldDB

No variants for A2QY22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2QY22

No associated diseases with A2QY22

5 regional properties for A2QY22

Type Name Position InterPro Accession
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 387 - 396 IPR002464
domain Helicase-like, DEXD box c2 type 6 - 436 IPR006554
domain ATP-dependent helicase, C-terminal 650 - 847 IPR006555
domain RAD3-like helicase, DEAD 205 - 414 IPR010614
domain Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type 4 - 444 IPR014013

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
DNA-templated DNA replication maintenance of fidelity A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.
establishment of sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase.
interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.
mitotic sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELQRNDFHH PYSPYDIQLQ LMRALYSCLE QGKVAVFESP TGTGKSLSLI CGSLTWLRDH
70 80 90 100 110 120
KRSAFQTAVD NATCDDDEPE WMLDFARRES SRMMTEKRKE LEERLEKTRK EEEQQRIALE
130 140 150 160 170 180
NPEGPRKKQK YSIPLTESGG LSEDQFALDD YDSENEEHSK PRDELAHTSE LSPSTLELLE
190 200 210 220 230 240
RFKGQISTAK PGSDDADNDE VKIFYCSRTH SQLTQFAGEL RRVKMPWSIP KDLLSTDLTG
250 260 270 280 290 300
EEELEERVKH VTLGSRKNLC INPRVSSLEN ATAINERCLD LQQPNVNPQH RCPFLPSKED
310 320 330 340 350 360
ERQVLQFRDH ALSTVKDIED LGKLGKKIGI CPYYASRSVV KDSEVCCLRA RSSIDLVPDE
370 380 390 400 410 420
WQIVTLPYPL LLQRSAREAL NSSVKGHVII IDEAHNLMDA ISNIHSVTVT LSQLQTSLSQ
430 440 450 460 470 480
LTIYGRKFKT RLKGKNRSYV AQVIRLLSSI AAHLRSLLES GKAPEGPVLI SELMSGKGVD
490 500 510 520 530 540
QINPYKLSRY LQESKLARKV DGYVEFTRDP SDKQASRSPT VPVLFHIQGF LLSLMNPSAE
550 560 570 580 590 600
GRLFYSKEQG DIQLKYMLLD PTNQFRELVE DARAIILAGG TMSPMTDYMN HLFSYVPASR
610 620 630 640 650 660
LDTFSYGHVI PPENLIAHTL VRGVQGSEFD FTYDARDSEK MIMDLGRTIA TLCHVIPDGV
670 680 690 700 710 720
VAFFPSYDYL GRVLNIWKKP MLGEQGQTVY NLIGQKKPIL SESRDMTVTT EELLHTYANT
730 740 750 760 770 780
VDSGRGALLL SVVGGKLSEG INFSDKLGRG VLIVGLPFPN IRSAVWQAKI QYIEQKTHQQ
790 800 810 820 830 840
ATGSEASRQL AAKAAGRDFY ENSCMRAVNQ CIGRAIRHRN DYAAIVLVDR RYEKPGIQAK
850 860 870
LPAWIKQSMV GSSVQRPAGA TVQSLAKFFA SKST