A2QP30
Gene name |
nudF |
Protein name |
Nuclear distribution protein nudF |
Names |
Lissencephaly-1 homolog, LIS-1 |
Species |
Aspergillus niger (strain CBS 51388 / FGSC A1513) |
KEGG Pathway |
ang:ANI_1_996064 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2QP30
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2QP30-F1 | Predicted | AlphaFoldDB |
No variants for A2QP30
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2QP30 | |||||
No associated diseases with A2QP30
9 regional properties for A2QP30
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 102 - 185 | IPR001680-1 |
| repeat | WD40 repeat | 189 - 334 | IPR001680-2 |
| repeat | WD40 repeat | 336 - 443 | IPR001680-3 |
| domain | LIS1 homology motif | 9 - 41 | IPR006594 |
| conserved_site | WD40 repeat, conserved site | 216 - 230 | IPR019775-1 |
| conserved_site | WD40 repeat, conserved site | 258 - 272 | IPR019775-2 |
| repeat | G-protein beta WD-40 repeat | 128 - 142 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 216 - 230 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 321 - 335 | IPR020472-3 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| microtubule associated complex | Any multimeric complex connected to a microtubule. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dynein complex binding | Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| microtubule sliding | The movement of one microtubule along another microtubule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTKILTSSQA | EELHKSIIAY | LSSINASRSC | EVLREELQVD | SSFDDALCRK | YEGLLEKKWT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GIARLQKKIL | DLESKLAGLQ | TELDTISPTA | RSTGKDPINW | LPTSSRHTFE | SHRDAVTCVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FHPVFTSLAS | GSEDCTIKIW | DWELGELERT | LKGHMRPVSD | LDFGGQKGHT | ILASCSSDLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKLWDPNKDY | ANVRTLSGHD | HSVSAVRFLR | QTDNILISAS | RDATIRIWDV | STGYCVKVID |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQGSWINDVS | PSFDGKWLVT | GGRDQAAMVW | EVASAKSVAS | LIGHENFIEC | CVFAPPSSYK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HLAAIAGLKT | APPASSSSEF | IATGARDKTI | KLWESRGRLI | KTLVGHDNWV | RGLLFHPGGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YLISVADDKT | IRCWDLSQGG | RLVKTINAHG | HFVSCIRWGP | VPVSDVPVET | SESTKSSKSD |
| 430 | 440 | ||||
| SVKPGFQCVI | ATGSADSSVR | IFT |