Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2QNQ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2QNQ8-F1 | Predicted | AlphaFoldDB |
No variants for A2QNQ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2QNQ8 | |||||
No associated diseases with A2QNQ8
1 regional properties for A2QNQ8
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain | 333 - 535 | IPR032319 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| polynucleotide 5'-hydroxyl-kinase activity | Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRKAEKAQA | AAPVSAFAAR | KARQQQAQAT | AAAVKPPVAE | PVVEPPPKRA | RRSLEEPVVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VAPEENRVQT | RRSSRRKEEQ | AKVEKPTPKA | RNDQPPKASK | KLPEHDTSKA | TEDQAPSDEE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEEPDVVVGN | TGVIGLEPIQ | NEEEGYESPA | DTAVQVQDFP | LSKARLNKNS | IVYSDEHRMC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRIKEKMSLV | MIGHYDLWVK | RGVVSLMGAK | LHPSSQVYRV | YAPSTHSLPV | IKCVSGVNGE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEVEFKSCHS | GIYRLKELSP | LYQRIWNGKN | TTADKLTLKG | TPQSTKRTFS | VLYTSADDSF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KRHLRPLHLE | KQWSSAIKSL | SQRGGRLKTL | ICGPKGSGKS | TFSRYLLNHL | LSPAPQTETK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| YFNTDGVAFL | DLDPGQPEFA | PMGQVYLAHL | RSPVFGPPFS | HPSLDGSRNG | TIVRSHHIGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TSPKEDPDHY | VLAAMDLMDR | YRALQASYPQ | CPLIINYPGW | IFGLGLEVAT | WLVRSLGLSD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVYMSEKGPT | EVVQPLGQAA | YQAKIPLTIL | PSQPTDFVSR | SSAQLRSMQM | QSYFHMSRPN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GINNSLWLEQ | PLSRTKPFRV | HYSGPQQGIQ | GIMVMGTEIH | PDLLHEVLDG | SIVAVVAVES |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PNAILGQNSG | PMFANNANAE | TDGDHDVDMQ | DSADAVPVIG | TSTIESSITR | TPNEDLPYLF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VGAGSSNPLD | PKVSHCLGLA | LVRSVNVASR | QLELVTPITG | STLRGVLEQG | HSIVLVRGLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DNPNWAISED | YYAARAAEKR | HRELIEKLKK | DKGAAAAEDA | TLESEKQVLK | DRIRRASKVP |
| 790 | 800 | 810 | |||
| WMTVVEDNSR | RQREAAQREK | SLWKLRKKAY | PGSDSEGDW |