A2PZA5

PR
Gene name
PaFS
Protein name
Fusicoccadiene synthase
Names
FS, Fusicoccin A biosynthetic gene clusters protein 1, PaDC4:GGS
Species
Phomopsis amygdali (Fusicoccum amygdali)
KEGG Pathway
ag:BAF45924
EC number
2.5.1.29: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

322-433 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for A2PZA5

Entry ID Method Resolution Chain Position Source
5ER8 X-ray 250 A A/B 1-344 PDB
5ERM X-ray 230 A A/B 1-344 PDB
5ERN X-ray 243 A A/B 389-719 PDB
5ERO X-ray 255 A A/B/C 389-719 PDB
7JTH EM 400 A A/B/C/D/E/F/G/H 1-719 PDB
8EAX EM 373 A A/B/C/D/E/F/G/H 1-719 PDB
AF-A2PZA5-F1 Predicted AlphaFoldDB

No variants for A2PZA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2PZA5

No associated diseases with A2PZA5

2 regional properties for A2PZA5

Type Name Position InterPro Accession
binding_site Adenylosuccinate synthase, GTP-binding site 98 - 105 IPR018220
active_site Adenylosuccinate synthase, active site 221 - 232 IPR033128

Functions

Description
EC Number 2.5.1.29 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
farnesyltranstransferase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEFKYSEVVE PSTYYTEGLC EGIDVRKSKF TTLEDRGAIR AHEDWNKHIG PCGEYRGTLG
70 80 90 100 110 120
PRFSFISVAV PECIPERLEV ISYANEFAFL HDDVTDHVGH DTGEVENDEM MTVFLEAAHT
130 140 150 160 170 180
GAIDTSNKVD IRRAGKKRIQ SQLFLEMLAI DPECAKTTMK SWARFVEVGS SRQHETRFVE
190 200 210 220 230 240
LAKYIPYRIM DVGEMFWFGL VTFGLGLHIP DHELELCREL MANAWIAVGL QNDIWSWPKE
250 260 270 280 290 300
RDAATLHGKD HVVNAIWVLM QEHQTDVDGA MQICRKLIVE YVAKYLEVIE ATKNDESISL
310 320 330 340 350 360
DLRKYLDAML YSISGNVVWS LECPRYNPDV SFNKTQLEWM RQGLPSLESC PVLARSPEID
370 380 390 400 410 420
SDESAVSPTA DESDSTEDSL GSGSRQDSSL STGLSLSPVH SNEGKDLQRV DTDHIFFEKA
430 440 450 460 470 480
VLEAPYDYIA SMPSKGVRDQ FIDALNDWLR VPDVKVGKIK DAVRVLHNSS LLLDDFQDNS
490 500 510 520 530 540
PLRRGKPSTH NIFGSAQTVN TATYSIIKAI GQIMEFSAGE SVQEVMNSIM ILFQGQAMDL
550 560 570 580 590 600
FWTYNGHVPS EEEYYRMIDQ KTGQLFSIAT SLLLNAADNE IPRTKIQSCL HRLTRLLGRC
610 620 630 640 650 660
FQIRDDYQNL VSADYTKQKG FCEDLDEGKW SLALIHMIHK QRSHMALLNV LSTGRKHGGM
670 680 690 700 710
TLEQKQFVLD IIEEEKSLDY TRSVMMDLHV QLRAEIGRIE ILLDSPNPAM RLLLELLRV