A2CBU3

PR
Gene name
metK
Protein name
S-adenosylmethionine synthase
Names
AdoMet synthase, MAT, Methionine adenosyltransferase
Species
Prochlorococcus marinus (strain MIT 9303)
KEGG Pathway
pmf:P9303_22181
EC number
2.5.1.6: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2CBU3

Entry ID Method Resolution Chain Position Source
AF-A2CBU3-F1 Predicted AlphaFoldDB

No variants for A2CBU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2CBU3

No associated diseases with A2CBU3

5 regional properties for A2CBU3

Type Name Position InterPro Accession
domain S-adenosylmethionine synthetase, N-terminal 4 - 102 IPR022628
domain S-adenosylmethionine synthetase, central domain 122 - 249 IPR022629
domain S-adenosylmethionine synthetase, C-terminal 251 - 396 IPR022630
conserved_site S-adenosylmethionine synthetase, conserved site 123 - 133 IPR022631-1
conserved_site S-adenosylmethionine synthetase, conserved site 277 - 285 IPR022631-2

Functions

Description
EC Number 2.5.1.6 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.

2 GO annotations of biological process

Name Definition
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
S-adenosylmethionine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRYVFTSES VTEGHPDKIC DQVSDAVLDA LLAQDPSSRV ACETVVNTGL CLITGEVTSN
70 80 90 100 110 120
SQVDFIHLVR NVIREIGYSG ARAGGFDATS CAVLVALDQQ SPDIAQGVNE ADDHSGDPLD
130 140 150 160 170 180
KVGAGDQGIM FGYACDDTPE LMPLPISLAH RLARQLAAVR HDGSLSYLLP DGKTQVSVVY
190 200 210 220 230 240
ENDRPVAIDT ILISTQHTSE VEGISDENGI RERITQDLWT HVVEPATADL PLKPNREATR
250 260 270 280 290 300
FLVNPTGKFV VGGPQGDAGL TGRKIIVDTY GGYARHGGGA FSGKDPTKVD RSAAYAARFV
310 320 330 340 350 360
AKCLVAAGLA QRAEVQLSYA IGVAKPVSIL VESFGTGKVT NDELTALVQD HFDLRPGAII
370 380 390 400 410
EQFKLRQLPQ QRGGRFYQDT AAYGHFGRPD LNLPWEDVTD KASTLLQAEA QQQKQGSSL