A2BK91

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)
KEGG Pathway
hbu:Hbut_0542
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2BK91

Entry ID Method Resolution Chain Position Source
AF-A2BK91-F1 Predicted AlphaFoldDB

No variants for A2BK91

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2BK91

No associated diseases with A2BK91

2 regional properties for A2BK91

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 91 - 400 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 404 - 558 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNAVGHGGR AAVGPVMGKI MAERPDLRPQ AKQIVAIVRE VVEEVNKLSL EEQKRLLEEK
70 80 90 100 110 120
YSWVIEKKLQ KRREAVEKKL PPLPDAEEGR VVTRFAPNPD FVIHLGNARP ALLSYEYAVM
130 140 150 160 170 180
YRGKMILRFE DTDPRIKTPL PEAYELIRED LKWLGIRWDE EYIQSLRMHI YYDIARKLIE
190 200 210 220 230 240
VGGAYVDDRS PEEFRRYRDE GRLEDYPPRK RSVEENLELW DKMVSGAFGE GEAVLRVKTD
250 260 270 280 290 300
PRHPDPSVRD WVAFRIIDTS RYPHPLVGDR YVAWPTYNFA AAVDDKLMGV THILRAKEHM
310 320 330 340 350 360
QNTIKQQFLY KHLGWSYPHV VHFGRLKLEG FIMSKSTLKR FLDAGISRGI DDPRFATIAG
370 380 390 400 410 420
LRRRGIVPEA IKKLIMEVGV KYTDASISYD NLAAINRSII DPRAKRIMAA LSPVPVEVEG
430 440 450 460 470 480
LPWREKEFRI PFHPSGQLGE RIVKLAGPKA TIYVSQSDAV QLAKGNIVRL MEAFNIEVLG
490 500 510 520 530 540
ASPRRVRARY HSLTVDEARQ HNAPIIQWVP ATDNIAVEVL KPEGLDLVQE RGLAEPAAAQ
550 560 570
LKPGEIIQLV RIGFARVDSV ETDEKGKVRK VVLIYAHD