A2BE28
PR
Gene name |
Las1l |
Protein name |
Ribosomal biogenesis protein LAS1L |
Names |
Protein LAS1 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:76130 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2BE28
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2BE28-F1 | Predicted | AlphaFoldDB |
64 variants for A2BE28
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389577482 | 22 | S>I | No | EVA | |
| rs3411296601 | 29 | S>T | No | EVA | |
| rs3410370983 | 30 | W>C | No | EVA | |
| rs3408715118 | 33 | R>S | No | EVA | |
| rs3411177548 | 33 | R>T | No | EVA | |
| rs3389572757 | 46 | D>E | No | EVA | |
| rs3389572782 | 70 | P>S | No | EVA | |
| rs3409877306 | 71 | L>R | No | EVA | |
| rs3408715159 | 71 | L>V | No | EVA | |
| rs3389536106 | 102 | M>T | No | EVA | |
| rs3410371002 | 129 | E>G | No | EVA | |
| rs3389566860 | 154 | C>Y | No | EVA | |
| rs3409877332 | 164 | W>R | No | EVA | |
| rs3409765046 | 167 | K>* | No | EVA | |
| rs3411177536 | 168 | T>S | No | EVA | |
| rs3411174467 | 172 | R>H | No | EVA | |
| rs3389566824 | 174 | L>P | No | EVA | |
| rs3411064417 | 177 | S>N | No | EVA | |
| rs3389477384 | 178 | L>M | No | EVA | |
| rs255669168 | 183 | E>G | No | EVA | |
| rs3409877280 | 188 | Q>K | No | EVA | |
| rs237282774 | 189 | L>V | No | EVA | |
| rs1131985954 | 197 | E>G | No | EVA | |
| rs1135128629 | 199 | R>G | No | EVA | |
| rs212322170 | 201 | I>L | No | EVA | |
| rs3389577464 | 232 | G>S | No | EVA | |
| rs3389561287 | 246 | H>Y | No | EVA | |
| rs249224423 | 271 | H>D | No | EVA | |
| rs3389566879 | 271 | H>L | No | EVA | |
| rs249224423 | 271 | H>Y | No | EVA | |
| rs3389569227 | 272 | R>M | No | EVA | |
| rs3389561317 | 277 | A>V | No | EVA | |
| rs3389580126 | 285 | S>F | No | EVA | |
| rs1132777194 | 287 | R>C | No | EVA | |
| rs3389517799 | 295 | L>F | No | EVA | |
| rs3389477390 | 308 | D>Y | No | EVA | |
| rs3389577526 | 312 | D>N | No | EVA | |
| rs3411220657 | 315 | F>I | No | EVA | |
| rs3389582488 | 337 | V>L | No | EVA | |
| rs387758828 | 393 | V>M | No | EVA | |
| rs3411177577 | 415 | T>S | No | EVA | |
| rs3410370034 | 417 | T>S | No | EVA | |
| rs3411174504 | 443 | T>S | No | EVA | |
| rs3389580129 | 448 | Q>P | No | EVA | |
| rs3411220633 | 502 | A>E | No | EVA | |
| rs3411332545 | 504 | E>Q | No | EVA | |
| rs1133522925 | 524 | D>N | No | EVA | |
| rs217622854 | 527 | P>L | No | EVA | |
| rs1134581344 | 537 | S>R | No | EVA | |
| rs1134192908 | 568 | E>K | No | EVA | |
| rs582426982 | 571 | E>G | No | EVA | |
| rs585238339 | 581 | E>D | No | EVA | |
| rs3389517843 | 637 | D>G | No | EVA | |
| rs3389517786 | 641 | D>H | No | EVA | |
| rs3389582448 | 688 | W>D | No | EVA | |
| rs1134015063 | 709 | D>G | No | EVA | |
| rs3411443718 | 722 | I>L | No | EVA | |
| rs3389567742 | 725 | R>Q | No | EVA | |
| rs3408715101 | 725 | R>W | No | EVA | |
| rs3409765101 | 734 | S>R | No | EVA | |
| rs1132469587 | 740 | C>Y | No | EVA | |
| rs1132336744 | 743 | S>N | No | EVA | |
| rs29087271 | 754 | G>C | No | EVA | |
| rs29087271 | 754 | G>S | No | EVA |
No associated diseases with A2BE28
No regional properties for A2BE28
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A2BE28 | |||
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Las1 complex | A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448). |
| MLL1 complex | A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA | Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
| maturation of LSU-rRNA | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9Y4W2 | LAS1L | Ribosomal biogenesis protein LAS1L | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDRVWRAWDG | QSFKENQPES | PSARGIVVSW | LSRAEWEQVT | VYLFCDDHKL | QQYALNRITV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WRSRLGNELP | LAVASTADLV | RCKLIDAAGT | LGTDELRLLY | GMALVRFVNL | ISERKTKCSN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPLKYLAQEV | NIPDWIVELR | HNLTHKKMPH | INECRRGCYF | VLNWLQKTYW | SRQLEGSLKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TWELDEDQLD | AEDPEEEERE | IIADDVLEEI | PEPQDDDKDE | ELAVEDDANT | KGNEEVASHP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPSSRHKELY | EKARELLVSY | EEEQFKVLEK | HRHLLQAIKV | WNNLSPRVQC | ILEELKSISW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ENRDAVLDAF | LDDGFLIPTF | EQLAALQIEY | EDGQTEVQKG | EVTEPNSHKN | IDLNEVLVPK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PFSQFWQPLL | RGLHSQTFTQ | ALLERMFSEL | STVGSTGIRP | TYILRWTVEL | IVANTKTGRN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ARRFSASQWE | ARKSWRLFNC | SATLDWPQVI | ESCLGSPCWA | SPQLLQVVFK | AMGQVLPDEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QEKLLRVCSI | YTQNGENGLA | KAIEGSSSSS | TGKAPYTLDT | LHEDLQPPGT | NCESEESIQQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KEQGNLKDVK | QEEKKENEEE | EKEEEEMEEE | EEEEEEEKEE | EEEEQEQEEH | QEEEQEEEEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| EENQKVFQDQ | MEADVEESDD | VEEEEEVDDE | EEDEDDDYDD | DEEEDRMEVG | AFSLAQGSSV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FENTRTTSRK | REALQGSAWQ | VSSEDVRWGT | FPLGRLPGQT | EDPAELMLDN | YDTMYLLDQP |
| 730 | 740 | 750 | 760 | 770 | |
| VIEHRLEPQK | SKSSTLSLCC | GGSNTNSSSS | SSSGNMEGLL | WNQGQMHGLK | AGLQLF |