A2ALW5
Gene name |
Dnajc25 |
Protein name |
DnaJ homolog subfamily C member 25 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:72429 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2ALW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2ALW5-F1 | Predicted | AlphaFoldDB |
11 variants for A2ALW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs212419370 | 14 | A>T | No | EVA | |
| rs252903698 | 63 | E>D | No | EVA | |
| rs3412117866 | 130 | H>L | No | EVA | |
| rs3394310472 | 157 | S>P | No | EVA | |
| rs3388690791 | 158 | M>K | No | EVA | |
| rs3388688260 | 161 | Y>F | No | EVA | |
| rs245528946 | 239 | R>W | No | EVA | |
| rs3388688020 | 240 | D>V | No | EVA | |
| rs3388683356 | 289 | M>I | No | EVA | |
| rs3388681823 | 297 | L>Q | No | EVA | |
| rs3388691426 | 309 | E>* | No | EVA |
No associated diseases with A2ALW5
1 regional properties for A2ALW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DnaJ domain | 47 - 121 | IPR001623 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5HZT9 | dnajc25 | DnaJ homolog subfamily C member 25 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARLALRGG | PGAAGQRPWL | LLAPLLLVPL | LARPAEALVE | GLYCGTRDCY | EVLGVSRSAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KAEIARAYRQ | LARRYHPDRY | RPEPGDGPGG | APPSAEAFLL | VATAYETLKD | EETRKDYDYM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDHPEEYYSH | YYHYYSRRLA | PKVDVRVVIL | VSVCAISMFQ | YFSWWNSYNK | AISYLATVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YRIQATEIAK | EQGLLKKAKE | KGKNKKSKEE | IRDEEENIIK | NIIKSKIDIK | GGYQKPQVRD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLLFQVILAP | VHLCSYIAWY | CRWIYNFNIK | GKEYGEEERL | YIIRKSMKMS | QSQFDSLEDH |
| 310 | 320 | 330 | 340 | 350 | |
| QKEMFLKREL | WIKENYEVYK | QEQEEELKKK | LANDPRWKRY | RRWMKNEGPG | RLTFVDD |