A2A1A0

PR
Gene name
NCS1
Protein name
S-norcoclaurine synthase 1
Names
CjNCS1
Species
Coptis japonica (Japanese goldthread)
KEGG Pathway
EC number
4.2.1.78: Hydro-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

177-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2A1A0

Entry ID Method Resolution Chain Position Source
AF-A2A1A0-F1 Predicted AlphaFoldDB

No variants for A2A1A0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2A1A0

No associated diseases with A2A1A0

3 regional properties for A2A1A0

Type Name Position InterPro Accession
domain Oxoglutarate/iron-dependent dioxygenase 200 - 304 IPR005123
domain Non-haem dioxygenase N-terminal domain 51 - 160 IPR026992
domain Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain 223 - 304 IPR044861

Functions

Description
EC Number 4.2.1.78 Hydro-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
(S)-norcoclaurine synthase activity Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O.
metal ion binding Binding to a metal ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

1 GO annotations of biological process

Name Definition
alkaloid metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKNLTGVGG SLPVENVQVL AGKELKNLPN RYVRPELEHD DVVPIDNSLE IPVIDLSRLL
70 80 90 100 110 120
DQQYACDELA KFHSACLDWG FFQLINHGVR EEVIEKMKVD TEDFFRLPFK EKNAYRQLPN
130 140 150 160 170 180
GMEGYGQAFV TSEEQKLDWA DMHFLITKPV QERNMRFWPT SPTSFRETME KYSMELQKVA
190 200 210 220 230 240
MCLTGMMAKN LGLESEILTK PLRTVFNRED ELLPSMSSCG EGLGLSPHSD ATGLTLLIQV
250 260 270 280 290 300
NEVNGLHIKK DEKWVPIKPI LGAFVVNIGD VIEIMSNGIY KSIEHRAVIN TDKERLSIAA
310 320 330 340 350
FHDPEYGTKI GPLPDLVKEN GVKYKTIDYE DYLIRSSNIK LDGKSLLDQM KL