A1WXK9

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Halorhodospira halophila (strain DSM 244 / SL1) (Ectothiorhodospira halophila (strain DSM 244 / SL1))
KEGG Pathway
hha:Hhal_1657
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

773-855 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1WXK9

Entry ID Method Resolution Chain Position Source
AF-A1WXK9-F1 Predicted AlphaFoldDB

No variants for A1WXK9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1WXK9

No associated diseases with A1WXK9

5 regional properties for A1WXK9

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 614 - 804 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 17 - 128 IPR007695
domain DNA mismatch repair protein MutS, core 279 - 598 IPR007696
domain DNA mismatch repair protein MutS, connector domain 137 - 261 IPR007860
domain DNA mismatch repair protein MutS, clamp 435 - 526 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAATQEAETA TNGAGHTPMM RQFLRIKAEY PETLLFYRMG DFYELFYEDA ERAAKLLDIT
70 80 90 100 110 120
LTTRGESAGA PIPMAGVPVQ SVESYLARLV RLGESVAICE QIGDPNTTKG PVERQVVRVV
130 140 150 160 170 180
TPGTLTEDAL LEERSANLLT AVAPGPKGRF GVASLELSSG RFSVLEAPDQ EALTAELERL
190 200 210 220 230 240
RPAELILPDD DQTPAPEGGC VAQRRPSWHF EYDSARRLLL RQLGTHDLSG FGAEELHAPV
250 260 270 280 290 300
TAAGALLQYL NETQRAALPH VGALTVESRD EAITIDAASR RNLEIEHNLS GGTEHTLASV
310 320 330 340 350 360
IDTSVTAMGG RLLRRWLQRP LRRRETIAAR HAAVAALADG AFADVRSTLE GCADVERILA
370 380 390 400 410 420
RVALGTARPR DLTGLRDALE RLPQLQILLG QLNSHRLQAL GVELDEHPQT VDLLQRAIID
430 440 450 460 470 480
TPPATVRDGG VIADGFDGEL DELRSMSRNA DDYLAALEAE ERAATGIPTL KVGFNRVHGY
490 500 510 520 530 540
YIEVSRSQSG HMPERYTRRQ TLKAAERFIT PELKRFEEQV LSARERALAR EKALYEQLVA
550 560 570 580 590 600
DLASELTPLQ RSASALAELD ALAAFAERAR SLDYVQPELA DTPGVRIEGG RHPVVEQALD
610 620 630 640 650 660
APFVPNDVRL DNRRRMLLIT GPNMGGKSTY MRQTALIALL AYAGAFVPAQ RAVLGPIDRI
670 680 690 700 710 720
FTRIGAADDL ASGRSTFMVE MTETANILHN ATAESLVLMD EIGRGTSTFD GLALAWATAE
730 740 750 760 770 780
RLATRIRAFT LFATHYFEMT ALEQIHPGVV NVHLEAAEHG ERIVFLHAVR DGPANQSYGL
790 800 810 820 830 840
QVAALAGVPQ EVLKAAREKL RSLESGDGGD TGSAQLPLFG PEPVFPPPAQ PEPEPDPIRE
850 860
AVENLDPDGL TPRDALETIY WLKAQCKE