A1WS75
Gene name |
queF |
Protein name |
NADPH-dependent 7-cyano-7-deazaguanine reductase |
Names |
7-cyano-7-carbaguanine reductase, NADPH-dependent nitrile oxidoreductase, PreQ(0) reductase |
Species |
Verminephrobacter eiseniae (strain EF01-2) |
KEGG Pathway |
vei:Veis_4790 |
EC number |
1.7.1.13: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1WS75
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1WS75-F1 | Predicted | AlphaFoldDB |
No variants for A1WS75
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A1WS75 | |||||
No associated diseases with A1WS75
1 regional properties for A1WS75
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal | 17 - 116 | IPR029139 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.7.1.13 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| preQ1 synthase activity | Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| queuosine biosynthetic process | The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNPPESSPLG | KASACVDQYD | ATLLFPIARA | DQRAELGISG | AAPFFGADLW | TAFELSWLNQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RGKPQVALAH | ITVPCETPRI | VESKSFKLYL | NSFSNTRFAD | AAQVQARIRA | DVSAAVWRGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ASAGSVGVTL | LGPDRFAQEL | MQELDGLSLD | RLDVQCTQYQ | PAPELLSAQH | DAAPVSERLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SQLLKSNCPV | TGQPDWASVQ | IAYRGPPIDQ | EGLLQYLVSF | RNHSGFHEQC | VERIFMDLWT |
| 250 | 260 | 270 | 280 | ||
| RCQPIELTVY | ARYTRRGGLD | INPLRTSHPQ | GLPRNMRTAR | Q |