A1WMN5

PR
Gene name
purA
Protein name
Adenylosuccinate synthetase
Names
AMPSase, AdSS, IMP--aspartate ligase
Species
Verminephrobacter eiseniae (strain EF01-2)
KEGG Pathway
vei:Veis_3162
EC number
6.3.4.4: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

93-164 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1WMN5

Entry ID Method Resolution Chain Position Source
AF-A1WMN5-F1 Predicted AlphaFoldDB

No variants for A1WMN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1WMN5

No associated diseases with A1WMN5

2 regional properties for A1WMN5

Type Name Position InterPro Accession
binding_site Adenylosuccinate synthase, GTP-binding site 15 - 22 IPR018220
active_site Adenylosuccinate synthase, active site 140 - 151 IPR033128

Functions

Description
EC Number 6.3.4.4 Other carbon--nitrogen ligases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
adenylosuccinate synthase activity Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
GTP binding Binding to GTP, guanosine triphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTATKGRNVV VVGTQWGDEG KGKLVDWLTQ SAQGVVRFQG GHNAGHTLVI NGVKTALHLI
70 80 90 100 110 120
PSGIMRPGVK CYIGNGVVLS AAKLFEEIEG LEKAGVEVRS RLRISEACPL ILPFHAAIDI
130 140 150 160 170 180
AREAAREQGG AEKIGTTGRG IGPAYEDKIA RRALRVQDLK HPERFAARLR ELLDLHNHLL
190 200 210 220 230 240
TTYLGSATFV FDAALKPYIE AGKVQFDVVH AEAMRHAELL KPMMADVSRE LNEAHRAGIN
250 260 270 280 290 300
LLFEGAQGTL LDVDHGTYPY VTSSNCVAGN AAAGSGVGPG MLHYILGITK AYCTRVGGGP
310 320 330 340 350 360
FPTELDWQVP GTPGYHMSLV GAEKGVTTGR SRRCGWFDAA LLKRSAQVNG LSGLCITKLD
370 380 390 400 410 420
VLDGLAELRL CTGYELDGAR IDLPPMGAED IIRCRPIYET LPGWSESTVG VTDYAKLPQN
430 440 450
ARRYLERIEQ VTGVPIDLIS TSPDRDHTIM MRHPYDAG