A1WIG8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Verminephrobacter eiseniae (strain EF01-2)
KEGG Pathway
vei:Veis_1670
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

810-872 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1WIG8

Entry ID Method Resolution Chain Position Source
AF-A1WIG8-F1 Predicted AlphaFoldDB

No variants for A1WIG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1WIG8

No associated diseases with A1WIG8

4 regional properties for A1WIG8

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 868 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 651 - 693 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 552 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 706 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSISVADIR KSFLDFFVAK GHTIVASSPL VPGNDPTLMF TNSGMVQFKD VFLGTDKRPY
70 80 90 100 110 120
SRAVSVQACL RAGGKHNDLE NVGYTARHHT FFEMLGNWSF GDYFKRESLQ WAWELLTEVY
130 140 150 160 170 180
RLPAERLLAT VYQDDDEAYD IWTREIGLPP ERVIRIGDNK GGRYKSDNFW MMADTGPCGP
190 200 210 220 230 240
CSEIFYDHGP GIPGGPPGSP DEDGDRFIEI WNNVFMQFNM AADGSVTPLP APCVDTGMGL
250 260 270 280 290 300
ERLAAVLQQV HSNYEIDLFE QLIAAASRET GEKDLGHKSL RVIADHIRAS AFLVSDGVLP
310 320 330 340 350 360
GSEGRGYVQR RIMRRAIRHG YQLGQRAPFL HRLVADLVRL MGAAYPSLRA QQQRIADILK
370 380 390 400 410 420
AEEERFFETL AHGMEILDAA LDGGAKLLPG DVAFKLHDTY GFPLDLSADM CRERGVAVDE
430 440 450 460 470 480
AGFHLAMERQ KTQARAAGKF KMERALEYTG GASRFTGYED LAGTAKITAI YAAGTSVAAL
490 500 510 520 530 540
KTGQHGVLVL DRTPFYAESG GQVGDQGLIS SGSARFAVDD TLKIKADVHG HHGRLEDGTL
550 560 570 580 590 600
NVGDTVQARV NTALRAATMR NHSATHLMHQ ALRAVLGSHV QQKGSLVNAE RTRFDFAHNA
610 620 630 640 650 660
AVSSAELREI ERRVNEEILA NQPTQARVMD IEAARSSGAM MLFDEKYGAA VRVLDIGSSR
670 680 690 700 710 720
ELCAGTHVQR TGDIGLFKVV AEGGVAAGVR RIEAVTGSHA LAWLQQLEDT VNQAADTLRA
730 740 750 760 770 780
PVAELNGRIS QALDNARALE KEVAALKSRL AASQGQELLA RAVQIKGLAV LAATLPGADA
790 800 810 820 830 840
KTLRATMDQL KDQLKTAAIV LAAVDGDKVQ LAAGVTADSV GRIQAGDLVN FVARQVGGKG
850 860 870
GGKPDMAMAG GTDAAGLPAA LASVAGWVSG RL