A1W8I2

PR
Gene name
pheS
Protein name
Phenylalanine--tRNA ligase alpha subunit
Names
Phenylalanyl-tRNA synthetase alpha subunit, PheRS
Species
Acidovorax sp (strain JS42)
KEGG Pathway
ajs:Ajs_2396
EC number
6.1.1.20: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1W8I2

Entry ID Method Resolution Chain Position Source
AF-A1W8I2-F1 Predicted AlphaFoldDB

No variants for A1W8I2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1W8I2

No associated diseases with A1W8I2

3 regional properties for A1W8I2

Type Name Position InterPro Accession
domain Phenylalanyl-tRNA synthetase 92 - 349 IPR002319
domain Phenylalanine-tRNA ligase, class II, N-terminal 20 - 87 IPR004188
domain Aminoacyl-tRNA synthetase, class II 116 - 340 IPR006195

Functions

Description
EC Number 6.1.1.20 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNELDSLVTS ARESFARSAT PAELENAKAQ FLGKSGRLTE LMKGMAQLSP EEKKTRGAAI
70 80 90 100 110 120
NVAKQAVEAA LAARRQELAD AELQAQLKAE ALDVTLPGRQ RGRGGLHPVS LTLERIERIF
130 140 150 160 170 180
GSMGFEVADG PEIETDWFNF TALNTPEDHP ARSMHDTFYV EGGTPEAPNL LRTHTSPMQV
190 200 210 220 230 240
RYAVQHVKKH RGLIDAGQAM PEIRVIAPGR TYRVDSDATH SPMFHQCEGL WIGENVSFKD
250 260 270 280 290 300
LKVVFTDFCK TFFESDDLVL RFRPSFFPFT EPSAEIDIQF QSGPLAGKWL EVAGSGQVHP
310 320 330 340
NVVRNMGLDP ERFIGFAFGM GPDRLTMLRY GVNDLRLFFD GDIRFLSQFQ