A1USC9
Gene name |
rpoC |
Protein name |
DNA-directed RNA polymerase subunit beta' |
Names |
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta' |
Species |
Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583) |
KEGG Pathway |
bbk:BARBAKC583_0572 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1USC9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1USC9-F1 | Predicted | AlphaFoldDB |
No variants for A1USC9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A1USC9 | |||||
No associated diseases with A1USC9
6 regional properties for A1USC9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA polymerase, alpha subunit | 346 - 487 | IPR000722 |
| domain | RNA polymerase, N-terminal | 237 - 516 | IPR006592 |
| domain | RNA polymerase Rpb1, domain 3 | 491 - 644 | IPR007066 |
| domain | RNA polymerase Rpb1, domain 1 | 17 - 344 | IPR007080 |
| domain | RNA polymerase Rpb1, domain 5 | 763 - 1312 | IPR007081 |
| domain | RNA polymerase Rpb1, domain 4 | 673 - 760 | IPR007083 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNHEVMNLFN | PQALAQIFDS | IRISIASPEN | ILSWSYGEIK | KPETINYRTF | KPERDGLFCA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIFGPIKDYE | CLCGKYKRMK | YKGIICEKCG | VEVTLSRVRR | ERMGHIELAA | PVAHIWFLKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPGRISTLLD | LTLKDIERIL | YFESYIVTEP | GLTSLKLHQL | LSEEEYMLAI | DKFGEDQFTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MIGAEAIYDL | LAGMELDKIA | NDLHAELAET | TSELKQKKLI | KRLKIVENFL | ESGNKPEWMI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MKTIPVIPPD | LRPLVPLDGG | RFATSDLNDL | YRRVINRNNR | LKRLIELRAP | GIIVRNEKRM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VQEAVDALFD | NGRRGRVITG | ANKRPLKSLS | DMLKGKQGRF | RQNLLGKRVD | YSGRSVIVTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PELKLHQCGL | PKKMALELFK | PFIYARLDAK | GYSSTVKQAK | KLVEKEHPEV | WDILDEVIRE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HPVLLNRAPT | LHRLGIQAFE | PVLIEGKAIQ | LHPLVCTAFN | ADFDGDQMAV | HVPLSLEAQL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EARVLMMSTN | NILHPANGAP | IIVPSQDMVL | GLYYLSIVSE | KEPGEGMAFA | DMGELHHALE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NKVVTLHTKI | KGRFKNIDKD | GKEVAQLYDT | TPGRLIIGEL | LPKNPNISFD | IVNQEMTKKN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LSKMIDQVYR | HCGQKETVVF | CDRIMQLGFS | HACRAGISFG | KDDMVIPESK | SRLVAETEAL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VKEYEQQYDD | GLITQGEKYN | KVVDAWGKCT | DRIADEMMKG | IQAVKFDPKT | GRQQRMNSIY |
| 730 | 740 | 750 | 760 | 770 | 780 |
| MMSHSGARGS | ANQMRQLAGM | RGLMAKPSGE | IIETPIISNF | KEGLTVNEYF | NSTHGARKGL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ADTALKTANS | GYLTRRLVDV | AQDAIISAVD | CGTIKGLTMQ | PIIDAGQIVA | SLGQRILGRT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ALLDILHPVS | GEVIIEGGTM | IEEADVLKIE | EARIQSVQIR | SALTCETRLG | VCAKCYGRDL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ARGTPVNQGE | AVGVIAAQSI | GEPGTQLTMR | TFHLGGTAQV | VDSSYFESSY | EGIVELRNRN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VVRNSEGHLV | VMGRNMAVLI | KDENGKERAV | HRISYGARLF | VDDGDIIKRG | QRIAEWDPYT |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RPILTEVDGY | VGFEDMVDGL | SVTETTDEST | GITKRQVIDW | RVNPRGADLK | PAMIIHSDKQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GKNIAKLHKG | GEARYVMSVE | TILSVEPGSH | VKAGDVIARL | PMESAKTKDI | TGGLPRVAEL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| FEARRPKDHA | IIAEISGTVR | FGRGYKNKRR | IIIEPNDETL | EPVEYLIPKG | KLFHLQEGDK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| IEKGDYILDG | NPAPHDILAI | KGVEALASYL | VNEIQEVYRL | QGVLINDKHI | EVIVRQMLQK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| VEITESGDSD | YIPGDNVDRI | ELDEINDHLI | AEGKKPASGT | PILLGITKAS | LQTPSFISAA |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| SFQETTRVLT | EAAVSGKIDT | LQGLKENVIV | GRLIPAGTGG | TIAQIRRIAT | VRDDLIVDEQ |
| 1390 | 1400 | ||||
| RKSSNDGISK | AMLTDMTANA | AAE |