A1TTU1

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp citrulli)
KEGG Pathway
aav:Aave_3834
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

527-618 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1TTU1

Entry ID Method Resolution Chain Position Source
AF-A1TTU1-F1 Predicted AlphaFoldDB

No variants for A1TTU1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1TTU1

No associated diseases with A1TTU1

7 regional properties for A1TTU1

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 13 - 24 IPR001412
domain tRNA-binding domain 600 - 706 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 574 - 706 IPR004495
domain Methionyl/Leucyl tRNA synthetase 6 - 406 IPR015413
domain Methioninyl-tRNA synthetase core domain 5 - 382 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 394 - 405 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 385 - 553 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPARKIFVTT ALPYANGNFH IGHIMEYIQA DIWVRFQRMQ GAEVNFVGAD DTHGAPIMIA
70 80 90 100 110 120
AEKAGKTPQQ FVADIAAGRK PYLEGFHIRF DNWHSTDAPE NHELARQIYR DLQAAGLIET
130 140 150 160 170 180
RTIEQFFDPE KNMFLPDRFI KGECPRCHAR DQYGDNCENC GAVYAPTDLI EPYSALSGAK
190 200 210 220 230 240
PVLKSSDHFF FQLSDPRCVA FLQEWTQDGR LQPEVANKVK EWFSVRTNPD GTTSEGLGDW
250 260 270 280 290 300
DISRDAPYFG IEIPDAPGKY FYVWLDAPVG YLASLKNLLE KRGQSYDDYV ADPQLEQVHF
310 320 330 340 350 360
IGKDIVTFHT LFWPAMLKFS GRKTPDAVFV HGFLTVNNGE KMSKSRGTGL DPLKYLGLGM
370 380 390 400 410 420
NAEWLRYYLA AKLNGRNEDI DFNAEDFMAR VNSDLIGKFV NIASRAAGFL TKRFGGRLGA
430 440 450 460 470 480
PDADGAALLE ALRAQAGAIA EAYERRDTAR AVRETMLLAD RVNEYVDARK PWELAKQEGQ
490 500 510 520 530 540
EAALQAACTT CIEAFRLLTL YLKPVLPALA AQVEAFLNVQ PLTFADAPAL LGEGHAIGAY
550 560 570 580 590 600
QHLMQRVDIK QLEALFEVPA AAAAPAAPAA NAAAEASAAA GAATEAPGGE HIAPTITIDD
610 620 630 640 650 660
FAKIDLRIAL IVNCEPVEGS TKLLRLTLDV GEGRHRNVFS GIASAYRPEE LVGKLTVMVA
670 680 690 700
NLAPRKMKFG VSEGMVLAAS HGDEKAHPGI HVLNPWPGAT PGMRVR