A1TRL4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Acidovorax citrulli (strain AAC00-1) (Acidovorax avenae subsp citrulli)
KEGG Pathway
aav:Aave_3035
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

886-948 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1TRL4

Entry ID Method Resolution Chain Position Source
AF-A1TRL4-F1 Predicted AlphaFoldDB

No variants for A1TRL4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1TRL4

No associated diseases with A1TRL4

5 regional properties for A1TRL4

Type Name Position InterPro Accession
domain DHHA1 domain 809 - 944 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 727 - 769 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 12 - 398 IPR018164-1
domain Alanyl-tRNA synthetase, class IIc, N-terminal 450 - 628 IPR018164-2
domain Alanyl-tRNA synthetase, class IIc, core domain 8 - 782 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKPTPPSSV ADIRKSFLDF FASKGHTVVP SSPLVPGNDP TLMFTNSGMV QFKDVFLGTD
70 80 90 100 110 120
KRPYVRATSV QACLRAGGKH NDLENVGYTA RHHTFFEMLG NWSFGDYFKR DSLKWAWELL
130 140 150 160 170 180
TEVYGLPKER LLATVYAEDD EAYDIWTKEI GLPPERVIRI GDNKGGRYKS DNFWMMADTG
190 200 210 220 230 240
PCGPCSEIFY DHGPHIPGGP PGSPDEDGDR FIEIWNNVFM QFDMAEDGSV TPLPAPCVDT
250 260 270 280 290 300
GMGLERLAAI LQHVHSNYEI DLFAALIQAA ARETGTADLA NPSLKVIADH IRATAFLVSD
310 320 330 340 350 360
GVIPSNEGRG YVQRRIVRRA IRHGYKLGRK TPFFHSLVKD LVAQMGDAYP KLREQEQRIT
370 380 390 400 410 420
EVLKAEEERF FETLANGMDL LDSALDIQLA SKALQNKTLR WFASEGREEK LVSFKDDVQV
430 440 450 460 470 480
AEAVLISDEL RSTEYMQRLK ETVPGLNEVK TLHSVIRDWS GLTLPGDLAF KLHDTYGFPL
490 500 510 520 530 540
DLTNDVCRER GVTVDEDGFK AAMDRQKAQA RAAGKFKMDK ALEYGGEANR FSGYDGLTES
550 560 570 580 590 600
AKIVAIYVDG TSAQALEAGQ NGVVVLDNTP FYAESGGQVG DQGVIHAGGA RFAVDDTLKI
610 620 630 640 650 660
RADVYGHHGR LESGTLRVGD AVQAEVDAAL RAATMRNHSV THIMHKALRE VLGSHVQQKG
670 680 690 700 710 720
SLVNAERTRF DFAHNAPVTD AQIREIERRV NEEILANTPT GARVMDIESA QKTGAMMLFG
730 740 750 760 770 780
EKYGETVRVL DIGTSRELCG GTHVARTGDI GLFKVVGESG VAAGVRRIEA VTGAGALAYL
790 800 810 820 830 840
QQLEDTVAKA AGALRAPAAE ITGRIGQALE QVKALEREVA ALKGKLASSQ GDELAGQAVD
850 860 870 880 890 900
VKGLKVLAAT LPGADAKTLR DTMDKLKDKL KSAAIVLAAV DGAKVQIAAG VTPDAMAKVK
910 920 930 940
AGELVNFVAS QVGGKGGGKP DMAMAGGTDA AALPAALASV AAWVGERA