A1SIB6

PR
Gene name
panB
Protein name
3-methyl-2-oxobutanoate hydroxymethyltransferase
Names
Ketopantoate hydroxymethyltransferase, KPHMT
Species
Nocardioides sp (strain ATCC BAA-499 / JS614)
KEGG Pathway
nca:Noca_2042
EC number
2.1.2.11: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1SIB6

Entry ID Method Resolution Chain Position Source
AF-A1SIB6-F1 Predicted AlphaFoldDB

No variants for A1SIB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1SIB6

No associated diseases with A1SIB6

No regional properties for A1SIB6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A1SIB6

Functions

Description
EC Number 2.1.2.11 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
3-methyl-2-oxobutanoate hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSGRAMSPE ETAPYGTGPA RAESAPDAPA PIKRIRTHHL REMKQRGEKF AMLTAYEQYA
70 80 90 100 110 120
AQTFDEAGIE VLLVGDSASN NVFANETSLP VTVDELIPLA RAVSRSVRRA LVVADLPFGS
130 140 150 160 170 180
YQASPEQAYL TAVRFMKEAN AHAVKLEGGI EMAPQVRKLT EGGIPVMAHI GFTPQSEHNL
190 200 210 220 230 240
GGYRVQGRGE AAARVVAEAV AMEQAGAFAV VMEMVPGDVA AEVTKSVSIP TIGIGAGLDC
250 260 270 280 290
DGQVLVWQDA FGLRTGRMPR FVKQYADLHG VLLQAARDYA ADVKAGTFPG PEHTF