A1SBA6

PR
Gene name
menD
Protein name
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Names
SEPHCHC synthase, Menaquinone biosynthesis protein MenD
Species
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
KEGG Pathway
saz:Sama_3460
EC number
2.2.1.9: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-41 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1SBA6

Entry ID Method Resolution Chain Position Source
AF-A1SBA6-F1 Predicted AlphaFoldDB

No variants for A1SBA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1SBA6

No associated diseases with A1SBA6

3 regional properties for A1SBA6

Type Name Position InterPro Accession
domain Thiamine pyrophosphate enzyme, TPP-binding 424 - 551 IPR011766
domain Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain 17 - 136 IPR012001
domain Menaquinone biosynthesis protein MenD, middle domain 189 - 402 IPR032264

Functions

Description
EC Number 2.2.1.9 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
manganese ion binding Binding to a manganese ion (Mn).
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

1 GO annotations of biological process

Name Definition
menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDHLHSSTAE LNLLWGSLIL EELTRHGVMH LCMAPGSRST PLTLAAAAQD KLTRHLHFDE
70 80 90 100 110 120
RGLGFLALGL AKASQAPVAI ITTSGTAVAN LYPAIVEASL THVPLIILSG DRPWELIGCG
130 140 150 160 170 180
ANQAIEQLGI FGGYARQLNL PTPDLRIGPE VLLSALDEQL ANLDRPLHIN CMYPEPLYPS
190 200 210 220 230 240
EHRFDQFDSY LSRLGQWQDT QVPYLSVANA SLSAFPPRDA MMRFVHGKGV IVAGTLTEAE
250 260 270 280 290 300
TPTELITLSQ KLGWPLLTDA QSQLRQHPGA IGHIDQLLLN PRARALLDQA ERVLVFGGRL
310 320 330 340 350 360
LSKRLISYLA EKDWHSYWQV LPHQERLDPS HSNKQLWLGR AGDVCALEWP RSSEANWAAS
370 380 390 400 410 420
LISLNQSVEQ DFIHHIDGGE FGEAQVIRAI AASHTAEQQL FIGNSLPVRL YDMFAPIGCC
430 440 450 460 470 480
AASTYTNRGA SGIDGLIATA CGVARHSGRP TTLILGDLSA LHDLNSLALA RDCQSPLVIV
490 500 510 520 530 540
VLNNDGGNIF NLLPVPTEEL RSDFYRLSHG LEFGYGAAMF GLPYDRAEDM EAFIDAYQAA
550 560 570
LEHPGASVIE VTVAQDQASN QIRRMAEWIR SR