A1SAJ8

PR
Gene name
ubiE
Protein name
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, Demethylmenaquinone methyltransferase
Species
Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)
KEGG Pathway
saz:Sama_3202
EC number
2.1.1.163: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1SAJ8

Entry ID Method Resolution Chain Position Source
AF-A1SAJ8-F1 Predicted AlphaFoldDB

No variants for A1SAJ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1SAJ8

No associated diseases with A1SAJ8

3 regional properties for A1SAJ8

Type Name Position InterPro Accession
domain Zinc finger, BED-type 65 - 132 IPR003656
domain HAT, C-terminal dimerisation domain 592 - 674 IPR008906
domain hAT-like transposase, RNase-H fold 459 - 555 IPR025525

Functions

Description
EC Number 2.1.1.163 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.
demethylmenaquinone methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine.
S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol.
S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+.
S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine.

4 GO annotations of biological process

Name Definition
aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2.
methylation The process in which a methyl group is covalently attached to a molecule.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDGTSNSTH FGFKTVEADK KADLVAGVFH SVAAKYDIMN DVMSFGIHRL WKRFTIETAG
70 80 90 100 110 120
ARPGMKVLDL AGGTGDLTAK FSRLVGDRGE VVLADINDSM LKVGRAKLRD LGVVGNVSYV
130 140 150 160 170 180
QANAEALPFP DNHFDIITIA FGLRNVTDKD AALRSMQRVL KPGGKLLVLE FSKPQHEVMR
190 200 210 220 230 240
KLYDLYSFKI LPKMGEFIAQ DAGSYEYLAE SIRMHPDQDT LKGMMQDAGL EQVDYINMTD
250
GVVALHRGYK F