A1RYD8

PR
Gene name
proS
Protein name
Proline--tRNA ligase
Names
Prolyl-tRNA synthetase, ProRS
Species
Thermofilum pendens (strain DSM 2475 / Hrk 5)
KEGG Pathway
tpe:Tpen_0817
EC number
6.1.1.15: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

347-477 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1RYD8

Entry ID Method Resolution Chain Position Source
AF-A1RYD8-F1 Predicted AlphaFoldDB

No variants for A1RYD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1RYD8

No associated diseases with A1RYD8

4 regional properties for A1RYD8

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 102 - 273 IPR002314
domain Anticodon-binding 291 - 387 IPR004154
domain Aminoacyl-tRNA synthetase, class II 46 - 284 IPR006195
domain Proline-tRNA ligase, class II, C-terminal 414 - 482 IPR016061

Functions

Description
EC Number 6.1.1.15 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

1 GO annotations of biological process

Name Definition
prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEQGITVSK SEDFSEWYSQ VLSKAGLVDL RYNVQGFVVH KPWLMRIIKA IYRFFEEELE
70 80 90 100 110 120
KTGHEPVLFP LVIPEENFEK EKEHVEGFKP EVFWVTQAGD EKLERRLALR PTSETAFYYM
130 140 150 160 170 180
YSYWIQSWRD LPLKLYQSVS VYRNEKNTRP LIRGREFLWI EAHDAFATHE EALNQIREDM
190 200 210 220 230 240
ENSRKVIWEK LGIPFLFLRR PPWDKFSGAE DTYAADTIMP DGRVLQISST HDLGQRFAKA
250 260 270 280 290 300
FNVTFLDKDG KRKYVWQTCY GPGIWRITAA LIAIHGDDKG LVLPMNVAPI QVVIVPIYYK
310 320 330 340 350 360
ESDKERVLEK CRKLEAMIRE AGYRVYLDAR EEYTPGWKFN DWELKGVPVR LEVGVREVET
370 380 390 400 410 420
GTVTVFRRDL RVKEKVADSE LISHIRKLEN DILEELKRRA KEFFESRIVT ATRREEVEEA
430 440 450 460 470 480
LRSGKMVKMP FCGREECADD LKEATDGGKV RGTEIDFKEG DYGRCAWCGA PARLIVYVAK
SY