A1RRX4

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
KEGG Pathway
pis:Pisl_0528
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1RRX4

Entry ID Method Resolution Chain Position Source
AF-A1RRX4-F1 Predicted AlphaFoldDB

No variants for A1RRX4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1RRX4

No associated diseases with A1RRX4

3 regional properties for A1RRX4

Type Name Position InterPro Accession
conserved_site Carbohydrate kinase, FGGY, conserved site 383 - 403 IPR018483
domain Carbohydrate kinase, FGGY, N-terminal 15 - 277 IPR018484
domain Carbohydrate kinase, FGGY, C-terminal 287 - 471 IPR018485

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYSVLEALR NNPDYVKKVL TARRLDTSLV DKFLELDKKW RQLKKEVDEL RHVYNQLSKE
70 80 90 100 110 120
GAKAPPERRR EIVEKARELA AKLENLEKEV EKIEREREDL LWSFPNLIHD SVPICPEGVD
130 140 150 160 170 180
SIPVRYGGVV KVAKDAVGTL KDVEYVIVDK LPIGHADMAE VVLGMVDTLK AGEVAGSRFY
190 200 210 220 230 240
YLLDDLVWLD FALAMYAMDR LAQKGFRPII PPYMLKFDVI KRVLDFDTFR DAIYKIEGED
250 260 270 280 290 300
LYLIATAEHG IAAYLYKREL VEDELPLLFV GWSPCFRKEA GAGSRDLKGI FRVHIFHKVE
310 320 330 340 350 360
QFVFSLPEDS WRWHEEITKN TEELIKDLGL PYRVVNICAH DLGAPAAKKY DIEVWYPAQS
370 380 390 400 410 420
MYRELASCSN VTDWQSYRLG IRVTRKGMRR EFVHTLNCTG LATTRTITAI LENFQREDGV
430 440
VEIPKVLRPY LEPIKAAPKD YIYPKKRS