A1RRG7

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)
KEGG Pathway
pis:Pisl_0371
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1RRG7

Entry ID Method Resolution Chain Position Source
AF-A1RRG7-F1 Predicted AlphaFoldDB

No variants for A1RRG7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1RRG7

No associated diseases with A1RRG7

2 regional properties for A1RRG7

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 101 - 408 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 411 - 557 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLEELVLKY ALANAVKYGG KADVKAVMSK IMAEVPELRP KAREVKSMVE AVVARVNSMS
70 80 90 100 110 120
LEEQLRLLRE RWPETLEERR VEQKRPGIEN LAELPNVKGG VVVRFAPNPD FVLHLGSARP
130 140 150 160 170 180
AILNYAYRLK YGGKFILRFE DTDPRTKKPL VTSEINAYET IREDLKWLGI KWDEEYIQSM
190 200 210 220 230 240
RMEIYYEHIK KLLEKGAAYV DLCRPEEWRK LRNAGRACPH REQSPEENLE LWDRMLEGRF
250 260 270 280 290 300
KEGEAVVRIK TDLSHPDPSV RDWVAFRIID TSKTPHPLVG DKYIVWPTYN FAVSIDDHLM
310 320 330 340 350 360
GITHVLRAQE HSVNTIKQSY IFKHFGWEQP VTIHFGRLKI EGASLSKSKL KALGVRYDDI
370 380 390 400 410 420
SLPTLAGLRN RGILPEAIWE LILTVGVKPS DSTIALSNLF ALNRKRIEPI ANRYMYVADP
430 440 450 460 470 480
IKLVFKSDRE LLAKIPLHPS FRERGERIYK FGPGTIELFV PRQDIKPGAV VRLMELANVE
490 500 510 520 530 540
IIAVENGVAH GRLHSVGIDE ARKVGAPIIQ WVYEPIEIHV VKPVAVGKKV EEIGLGESAL
550 560
EKVETGAYVQ FMRYGFLKKV GPSAFVYVHD