A1R8V3

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Paenarthrobacter aurescens (strain TC1)
KEGG Pathway
aau:AAur_2956
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

116-320 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1R8V3

Entry ID Method Resolution Chain Position Source
AF-A1R8V3-F1 Predicted AlphaFoldDB

No variants for A1R8V3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1R8V3

No associated diseases with A1R8V3

7 regional properties for A1R8V3

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 419 - 462 IPR000722-1
domain RNA polymerase, alpha subunit 470 - 560 IPR000722-2
domain RNA polymerase, N-terminal 310 - 589 IPR006592
domain RNA polymerase Rpb1, domain 3 564 - 722 IPR007066
domain RNA polymerase Rpb1, domain 1 9 - 417 IPR007080
domain RNA polymerase Rpb1, domain 5 829 - 1195 IPR007081
domain RNA polymerase Rpb1, domain 4 758 - 817 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSESSFGLM QIGLATAEDI RGWSYGEVKK PETINYRTLK PEKDGLFCEK IFGPSRDWEC
70 80 90 100 110 120
YCGKYKRVRF KGIICERCGV EVTRAKVRRE RMGHIELAAP VTHIWYFKGV PSRLGYLLDL
130 140 150 160 170 180
APKDLEKVIY FAAYMITSVD TESRHAELPN LQVEHDLEKK QMVDNRDSDI ATIARDLEDE
190 200 210 220 230 240
LARLEGEGAK AADKKKARDS ADRQMANVRK RADADIERLE QVWDRFKNLK VADLEGDEGL
250 260 270 280 290 300
YRELRDRYGL YFEGSMGAEA IKKRLETFDM QAEAESLRDT IQNGKGQRKT RALKRLKVVN
310 320 330 340 350 360
AFLTTNNSPL GMVLDAVPVI PPELRPMVQL DGGRFATSDL NDLYRRVINR NNRLKRLLDL
370 380 390 400 410 420
GAPEIIVNNE KRMLQEAVDS LFDNGRRGRP VTGPGNRPLK SLSDMLKGKQ GRFRQNLLGK
430 440 450 460 470 480
RVDYSGRSVI VVGPQLKLHQ CGLPKQMALE LFKPFVMKRL VDLNHAQNIK SAKRMVERYR
490 500 510 520 530 540
PQVWDVLEEI ITEHPVLLNR APTLHRLGIQ AFEPQLVEGK AIQLHPLVCG AFNADFDGDQ
550 560 570 580 590 600
MAVHLPLSPE AQAEARILML SSNNILKPSD GRPVTLPSQD MIIGLYHLTT KRVGSAGEGR
610 620 630 640 650 660
IFSSVSEAIM AYDARDLHLN SQVKIRLDDF VPYAGWEAPE GWEPGQPALV ETSLGQVIFN
670 680 690 700 710 720
QTLPEDYPWV EAVADKGELS RIVNDLAERY PKVVTAATLD NLKDAGFYWA TRSGVTVAIS
730 740 750 760 770 780
DIEVPTSKPA ILAGYENMAA KIQGQYDKGL IDDDERRQEL IEIWNKATNE IAQAMRDSLS
790 800 810 820 830 840
PMNTINRMVS SGARGNWMQV RQIAGIRGLV ANPKGEIIPR PIKSSYREGL SVLEYFIATH
850 860 870 880 890 900
GARKGLADTA LRTANSGYLT RRLVDVSQDV IVREEDCGTE RGLVTPIAVP DSNGELVLDE
910 920 930 940 950 960
NVENSAYART LAVDVVDAQG NVLAAGGTDC GDVVIDQLLA AGITEVKVRS VLTCESKVGT
970 980 990 1000 1010 1020
CALCYGRSLA TGKTVDIGEA VGIIAAQSIG EPGTQLTMRT FHTGGAVSAG GGDDITQGLP
1030 1040 1050 1060 1070 1080
RIQELFEART PKGVAPIAEA AGRITIEESE RQMRLVITPD DGSEEIAYPV LRRSRLLIED
1090 1100 1110 1120 1130 1140
GEHVSVGQKL INGPVDPKQV LRIMGPRAAQ KFLVDEVQGV YRSQGIGIHD KHVEVIVRQM
1150 1160 1170 1180 1190 1200
LRRVTVIESG DSDLLPGELA ERARFEDENR RVVSEGKAPA SGRPELMGIT KASLATESWL
1210 1220 1230 1240 1250 1260
SAASFQETTR VLTQAAMEGK SDPLLGLKEN VIIGKLIPAG TGLPRYTEVT VEPTEEAKAS
1270 1280 1290
LFTGPSAFTD FSYDALGGDG APEFHAIPLD DYDLGNDFR