A1R6X5

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Paenarthrobacter aurescens (strain TC1)
KEGG Pathway
aau:AAur_2246
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1R6X5

Entry ID Method Resolution Chain Position Source
AF-A1R6X5-F1 Predicted AlphaFoldDB

No variants for A1R6X5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1R6X5

No associated diseases with A1R6X5

5 regional properties for A1R6X5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 62 - 73 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 443 - 646 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 680 - 804 IPR013155
domain Methionyl/Leucyl tRNA synthetase 61 - 201 IPR015413
domain Leucyl-tRNA synthetase, editing domain 242 - 428 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVKPETETG TAQTAAAEAP EEGVYSFAAM EAKWPQVWED LKVFTPADDG SRERRYVLDM
70 80 90 100 110 120
FPYPSGDLHM GHAEAFAMGD VVARYLRQKG FDVLHPIGWD SFGLPAENAA IKRNAHPSEW
130 140 150 160 170 180
TYANIDTQAA SFKRYAISAD WSRRLHTSDP EYYRWTQWLF KRFYERGLAY RKDSPVNWCP
190 200 210 220 230 240
KDLTVLANEQ VVNGACERCG TPVTKKSLNQ WYFKITDYAD RLLEDMDQLQ GHWPERVLAM
250 260 270 280 290 300
QRNWIGRSEG AHVRFVIEAT ADRAEREVTV FTTRPDTLYG ATFFVVAADA HLALDLVTPE
310 320 330 340 350 360
QHDELMAYRE KVKALSEIER QSTEREKTGV FTGRYAINPL NGEKLPVWAA DYVLADYGTG
370 380 390 400 410 420
AIMAVPAHDQ RDLDFAKTFG LPVRAVLDTG DEDPAETGVA TAGEGTLKNS GELDGLSKSE
430 440 450 460 470 480
GIPAAIEILE KLGTGEKFVN FRLRDWLLSR QRFWGTPIPI IHCGECGEVP VPDDQLPVRL
490 500 510 520 530 540
PDDLRGEALS PKGTSPLAAA VEWVNVECPN CGRAAQRDTD TMDTFVDSSW YFLRFVSPDY
550 560 570 580 590 600
TEGPFDPEKI NNWMPVGQYV GGVEHAILHL LYARFFTKVI KDIGLIEANE PFSALLNQGQ
610 620 630 640 650 660
VLNGGKAMSK SLGNGVDLGE QLDKFGVDAV RLTMVFASPP EDDVDWADVS PSGSAKFLAR
670 680 690 700 710 720
AWRLGQDVSS EPGVDPATGD RALRTVTHKT IADAAELLDN NKFNVVVARL MELVNATRKT
730 740 750 760 770 780
IDSGAGAADP AVREAVEAVA VILSLFAPYT AEDLWNTLGH PASVANAGWP KHDDALLVQD
790 800 810 820 830 840
TVTAVVQVQG KVRDRLEVSP DITEDALREL ALASENVQRA LDGRGIRTVI VRAPKLVNIV
PA