A1KSY1
Gene name |
tgt |
Protein name |
Queuine tRNA-ribosyltransferase |
Names |
Guanine insertion enzyme, tRNA-guanine transglycosylase |
Species |
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) |
KEGG Pathway |
nmc:NMC0671 |
EC number |
2.4.2.29: Pentosyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1KSY1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1KSY1-F1 | Predicted | AlphaFoldDB |
No variants for A1KSY1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A1KSY1 | |||||
No associated diseases with A1KSY1
1 regional properties for A1KSY1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA-guanine(15) transglycosylase-like | 4 - 367 | IPR002616 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.4.2.29 | Pentosyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| queuine tRNA-ribosyltransferase activity | Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| queuosine biosynthetic process | The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. |
| tRNA-guanine transglycosylation | The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLKFTLHKKD | GYARRGTLEL | NHGKIETPVF | MPVGTYGSVK | AMNPQNLHDI | KAQIILGNTY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLWLRPGLEV | VEQFGGLHGF | IGWDKPILTD | SGGFQVFSLS | DMRKLTEEGC | TFKSPINGDK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LFLSPEISMK | IQTVLNSDIA | MQLDECTPGE | ATREQAKKSL | QMSLRWAERS | KKAFEDLKNP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NALFGIVQGA | MYEDLREESL | RGLEQFDFPG | LAVGGLSVGE | PKPEMYRMLR | AVGPILPEHK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PHYLMGVGTP | EDLVYGVAHG | IDMFDCVMPT | RNARNGWLFT | RFGDLKIKNA | KHKLDKRPID |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ESCTCYACQN | FSRAYLHHLH | RTGEILGAQL | NTIHNLHFYQ | VIMAEMREAV | EQGKFADWQA |
| 370 | |||||
| RFHENRARGT | D |