A1KSP4

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18)
KEGG Pathway
nmc:NMC0580
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

167-239 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1KSP4

Entry ID Method Resolution Chain Position Source
AF-A1KSP4-F1 Predicted AlphaFoldDB

No variants for A1KSP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1KSP4

No associated diseases with A1KSP4

3 regional properties for A1KSP4

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 292 - 301 IPR020557
domain Fumarate lyase, N-terminal 25 - 317 IPR022761
domain Argininosuccinate lyase, C-terminal 392 - 459 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHDKTWSGRF NEPVSELVKQ YTASIGFDRR LAEWDIQGSL AHAQMLKETG VLDEGDLADI
70 80 90 100 110 120
RRGMAEILEE IRSGKIEWSS DLEDVHMNIE RRLTDKIGDA GKRLHTGRSR NDQVATDIRL
130 140 150 160 170 180
WLRDQITVIR SLIQSLQTAL LDLAEQNAET VMPGFTHLQV AQPVSFGHHM LAYVEMLGRD
190 200 210 220 230 240
NERMADCRCR VNRMPLGAAA LAGTTYPIQR EITAELLGFE QICQNSLDAV SDRDFAIEFT
250 260 270 280 290 300
AAASLVMVHL SRLSEELILW MSPRFGFIDI ADRFCTGSSI MPQKKNPDVP ELVRGKSGRV
310 320 330 340 350 360
IGHLIGLITL MKSQPLAYNK DNQEDKEPLF DTADTLIDTL RIYADMMRGV TVKPDNMRAA
370 380 390 400 410 420
VMQGFATATD LADYLVKKGM PFRDAHEVVA QAVRHADEAG VDLSELPLEV LQGFSDLIAD
430 440 450
DVYGVLTPEG SLNARNHLGG TAPEQVRFQV KRWREMLA