A1KNP2

PR
Gene name
secA1
Protein name
Protein translocase subunit SecA 1
Names
Species
Mycobacterium bovis (strain BCG / Pasteur 1173P2)
KEGG Pathway
mbb:BCG_3269c
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

825-907 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1KNP2

Entry ID Method Resolution Chain Position Source
AF-A1KNP2-F1 Predicted AlphaFoldDB

No variants for A1KNP2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1KNP2

No associated diseases with A1KNP2

8 regional properties for A1KNP2

Type Name Position InterPro Accession
domain Helicase, C-terminal 419 - 620 IPR001650
domain SecA DEAD-like, N-terminal 2 - 383 IPR011115
domain SecA Wing/Scaffold 613 - 833 IPR011116
domain SecA, preprotein cross-linking domain 227 - 339 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 88 - 246 IPR014001
domain SecA motor DEAD 1 - 615 IPR014018
conserved_site SecA conserved site 481 - 496 IPR020937
domain SecA, C-terminal helicase domain 401 - 585 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSKLLRLGE GRMVKRLKKV ADYVGTLSDD VEKLTDAELR AKTDEFKRRL ADQKNPETLD
70 80 90 100 110 120
DLLPEAFAVA REAAWRVLDQ RPFDVQVMGA AALHLGNVAE MKTGEGKTLT CVLPAYLNAL
130 140 150 160 170 180
AGNGVHIVTV NDYLAKRDSE WMGRVHRFLG LQVGVILATM TPDERRVAYN ADITYGTNNE
190 200 210 220 230 240
FGFDYLRDNM AHSLDDLVQR GHHYAIVDEV DSILIDEART PLIISGPADG ASNWYTEFAR
250 260 270 280 290 300
LAPLMEKDVH YEVDLRKRTV GVHEKGVEFV EDQLGIDNLY EAANSPLVSY LNNALKAKEL
310 320 330 340 350 360
FSRDKDYIVR DGEVLIVDEF TGRVLIGRRY NEGMHQAIEA KEHVEIKAEN QTLATITLQN
370 380 390 400 410 420
YFRLYDKLAG MTGTAQTEAA ELHEIYKLGV VSIPTNMPMI REDQSDLIYK TEEAKYIAVV
430 440 450 460 470 480
DDVAERYAKG QPVLIGTTSV ERSEYLSRQF TKRRIPHNVL NAKYHEQEAT IIAVAGRRGG
490 500 510 520 530 540
VTVATNMAGR GTDIVLGGNV DFLTDQRLRE RGLDPVETPE EYEAAWHSEL PIVKEEASKE
550 560 570 580 590 600
AKEVIEAGGL YVLGTERHES RRIDNQLRGR SGRQGDPGES RFYLSLGDEL MRRFNGAALE
610 620 630 640 650 660
TLLTRLNLPD DVPIEAKMVT RAIKSAQTQV EQQNFEVRKN VLKYDEVMNQ QRKVIYAERR
670 680 690 700 710 720
RILEGENLKD QALDMVRDVI TAYVDGATGE GYAEDWDLDA LWTALKTLYP VGITADSLTR
730 740 750 760 770 780
KDHEFERDDL TREELLEALL KDAERAYAAR EAELEEIAGE GAMRQLERNV LLNVIDRKWR
790 800 810 820 830 840
EHLYEMDYLK EGIGLRAMAQ RDPLVEYQRE GYDMFMAMLD GMKEESVGFL FNVTVEAVPA
850 860 870 880 890 900
PPVAPAAEPA ELAEFAAAAA AAAQQRSAVD GGARERAPSA LRAKGVASES PALTYSGPAE
910 920 930 940
DGSAQVQRNG GGAHKTPAGV PAGASRRERR EAARRQGRGA KPPKSVKKR