A1DDD8

PR
Gene name
aglA (NFIA_073100)
Protein name
Probable alpha-galactosidase A
Names
Melibiase A
Species
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
KEGG Pathway
nfi:NFIA_073100
EC number
3.2.1.22: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1DDD8

Entry ID Method Resolution Chain Position Source
AF-A1DDD8-F1 Predicted AlphaFoldDB

No variants for A1DDD8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1DDD8

No associated diseases with A1DDD8

2 regional properties for A1DDD8

Type Name Position InterPro Accession
domain Ricin B, lectin domain 416 - 524 IPR000772
domain Alpha galactosidase, C-terminal beta sandwich domain 331 - 404 IPR041233

Functions

Description
EC Number 3.2.1.22 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

2 GO annotations of molecular function

Name Definition
carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
raffinose alpha-galactosidase activity Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose.

1 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYTTKSLLST LIPIMIPLSL GSVSSPNLLP TPPMGFNNWA RFMCDLNETL FLETASAMIS
70 80 90 100 110 120
TGLLEAGYNR LNLDDCWMAY DRAADSSLQW NTTKFPHGIP WLAYRLKTQG FHLGIYQDAG
130 140 150 160 170 180
NLTCGGYPGS FGYEALDAQT FAAWGIDYLK LDGCNVFPEH SRTLEEEYKA RYAHWHNVLR
190 200 210 220 230 240
QMHPPLIFSE SAPAYFADPA NLTSWYEVMD WVPAFGELAR HSTDILVYVG EGSAWDSIMV
250 260 270 280 290 300
NYHYNTLLAR YQRPGYFNDP DFLIPDHPGL TLEEKRSQFA LWASFSAPLI VSAYIPGLSG
310 320 330 340 350 360
EELAILRNEE LITVDQDVLG LQATLASRGE EVDVLTRSLA HGDQLLTVLN RGDGVPVVRV
370 380 390 400 410 420
PVEWMGLQRG CAYVVKNLWD GEVQVLEEEI VIRLNSHATQ VYRIALPEEC STVIPTGIVF
430 440 450 460 470 480
NTASGNCLTD ENGERVGFEA CRGSETQVWQ VSELGHLHPL SRTSHCLTAG SQASVQLCTG
490 500 510 520 530
QKNQQWTYEI TGNLKNEHTK MCLTEGTGIS QCGFERDSQV FGLPSGVDIK SS