A1D6T6
Gene name |
int6 (NFIA_065940) |
Protein name |
Eukaryotic translation initiation factor 3 subunit E |
Names |
eIF3e |
Species |
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus) |
KEGG Pathway |
nfi:NFIA_065940 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1D6T6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1D6T6-F1 | Predicted | AlphaFoldDB |
No variants for A1D6T6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A1D6T6 | |||||
No associated diseases with A1D6T6
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic 43S preinitiation complex | A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. |
| eukaryotic 48S preinitiation complex | A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. |
| eukaryotic translation initiation factor 3 complex, eIF3e | An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| eukaryotic translation initiation factor 3 complex assembly | The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex. |
| formation of cytoplasmic translation initiation complex | Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAANVPPSAE | TLLSGAAAHP | PKTAEEIANQ | YNLLPKLIPY | LDRHLVFPLL | EFSSGQDDEK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVVRAKYELL | KHTNMTDYVA | NLWKEINNSD | DIPDEFVKKR | EEVLAKLQQY | EEESAKITQL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LQDESVVANL | RSDKVANLKF | LEEQHGVTIE | MVNSLYDYGR | FQYSCGSYGN | AAELLYQFRV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSTDNDKVAS | ATWGKFASEI | LTTSWEAAME | EVQKVKDSIE | TRLFNNPLGQ | LQNRSWLIHW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLFPFFNHDP | ARDVLTDLFF | SPAYINTIQT | NCPWILRYLA | AAVITNRNRA | HKSSSVYQKQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LKDLIRVVRQ | EGYEYNDPIT | DFVKALYVDF | DFEEAQKKLG | EAEDVLRSDF | FLVSTTDAFV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EAARHLISES | YCKIHQRIDI | KDLSTRLGLN | QDEGEKWIVN | LIRDTRVDAK | IDYKEGTVIM |
| 430 | 440 | 450 | |||
| NHPPQSVYQQ | VIEKTKGAFF | RTQVLRFVRL | LYPHD |