A1D3C5

PR
Gene name
hulA (NFIA_016110)
Protein name
Probable E3 ubiquitin-protein ligase hulA
Names
HECT ubiquitin ligase A, HECT-type E3 ubiquitin transferase RSP5
Species
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
KEGG Pathway
nfi:NFIA_016110
EC number
2.3.2.26: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

112-357 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1D3C5

Entry ID Method Resolution Chain Position Source
AF-A1D3C5-F1 Predicted AlphaFoldDB

No variants for A1D3C5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1D3C5

No associated diseases with A1D3C5

5 regional properties for A1D3C5

Type Name Position InterPro Accession
domain C2 domain 1 - 112 IPR000008
domain HECT domain 462 - 816 IPR000569
domain WW domain 230 - 263 IPR001202-1
domain WW domain 334 - 367 IPR001202-2
domain WW domain 394 - 427 IPR001202-3

Functions

Description
EC Number 2.3.2.26 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell.
endosome membrane The lipid bilayer surrounding an endosome.
extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RSP5-BUL ubiquitin ligase complex A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

4 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

31 GO annotations of biological process

Name Definition
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
mitochondria-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions.
mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
positive regulation of fatty acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
protein monoubiquitination Addition of a single ubiquitin group to a protein.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of dolichol biosynthetic process Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.
regulation of ergosterol biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.
regulation of initiation of mating projection growth Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi.
regulation of mRNA export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm.
regulation of multivesicular body size Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles.
regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization.
regulation of phosphate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
regulation of ribosomal large subunit export from nucleus Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus.
regulation of rRNA processing Any process that modulates the frequency, rate or extent of rRNA processing.
regulation of tRNA export from nucleus Any process that modulates the frequency, rate or extent of tRNA export from nucleus.
regulation of tRNA processing Any process that modulates the frequency, rate or extent of tRNA processing.
regulation of ubiquinone biosynthetic process Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
ribophagy The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation.
ubiquitin-dependent endocytosis Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSNLPAQPN LRLTIIAADG LYKRDVFRFP DPFAVATVGG EQTHTTSVIK KTLNPYWNEM
70 80 90 100 110 120
FDLRVNEDSI LAIQIFDQKK FKKKDQGFLG VINVRIGDVI DLQMGGDEML TRDLKKSNDN
130 140 150 160 170 180
LVVHGKLIIN LSTNLSTPNT NQANGLHRSH VQSSTSSGLV PQVAPSSSHP AASGAAPVDP
190 200 210 220 230 240
SASNPSLNPQ RVPSTTRPSS TAAPASAAGA AASNTHGSRT NLSSFEDSQG RLPAGWERRE
250 260 270 280 290 300
DNLGRTYYVD HNTRTTTWTR PSSNYNEHAQ RSQREANMQL ERRAHQSRML PEDRTGANSP
310 320 330 340 350 360
NLPESSQQAH TPPAGGSANA VSMMATGATT AGTGELPPGW EQRTTPEGRP YFVDHNTRTT
370 380 390 400 410 420
TWVDPRRQQY IRMYGQNANG TNTTIQQQPV SQLGPLPSGW EMRLTNTARV YFVDHNTKTT
430 440 450 460 470 480
TWDDPRLPSS LDQGVPQYKR DFRRKLIYFR SQPALRIMSG QCHVKVRRNN IFEDSYAEIM
490 500 510 520 530 540
RQSASDLKKR LMIKFDGEDG LDYGGLSREF FFLLSHEMFN PFYCLFEYSA HDNYTLQINP
550 560 570 580 590 600
HSGVNPEHLN YFKFIGRVVG LAIFHRRFLD SFFIGAFYKM MLRKKVSLQD MEGVDEDLHR
610 620 630 640 650 660
NLTWTLDNDI EGVLELTFSV DDEKFGERRT IDLKPGGRDI PVTNENKAEY VELVTEWKIV
670 680 690 700 710 720
KRVEEQFNAF MSGFNELIPA DLVNVFDERE LELLIGGIAD IDVDDWKKHT DYRGYQESDE
730 740 750 760 770 780
VIQNFWKVVR SWDAEQKSRL LQFTTGTSRI PVNGFKDLQG SDGPRRFTIE KSGDPAALPK
790 800 810
SHTCFNRLDL PPYKSYETLE HKMSIAVEET LGFGQE