A1CUD6
Gene name |
nudF-1 |
Protein name |
Nuclear distribution protein nudF 1 |
Names |
Lissencephaly-1 homolog 1, LIS-1 1 |
Species |
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) |
KEGG Pathway |
act:ACLA_086220 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1CUD6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1CUD6-F1 | Predicted | AlphaFoldDB |
No variants for A1CUD6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A1CUD6 | |||||
No associated diseases with A1CUD6
9 regional properties for A1CUD6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 104 - 187 | IPR001680-1 |
| repeat | WD40 repeat | 191 - 343 | IPR001680-2 |
| repeat | WD40 repeat | 345 - 385 | IPR001680-3 |
| repeat | WD40 repeat | 388 - 466 | IPR001680-4 |
| domain | LIS1 homology motif | 9 - 41 | IPR006594 |
| conserved_site | WD40 repeat, conserved site | 225 - 239 | IPR019775 |
| repeat | G-protein beta WD-40 repeat | 130 - 144 | IPR020472-1 |
| repeat | G-protein beta WD-40 repeat | 225 - 239 | IPR020472-2 |
| repeat | G-protein beta WD-40 repeat | 330 - 344 | IPR020472-3 |
Functions
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| microtubule associated complex | Any multimeric complex connected to a microtubule. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dynein complex binding | Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| establishment of mitotic spindle orientation | A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. |
| microtubule sliding | The movement of one microtubule along another microtubule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQLLTTRQA | EELHKSIIAY | LASVNLSESA | TTLRAELGDA | VTIDDATIKK | YEGLLEKKWT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SVVRLQKKIM | DLESRCAALQ | SELDSATPTS | LLRKNQDPTA | WLPRAPPRHT | LESHRSPVTC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAFHPVFSSL | ASGSDDTTIK | IWDWELGELE | RTVKGHTKAV | LDVDYGGPRG | GTLLASCSSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LTIKLWDPSD | DYKNIRTLPG | HDHSVSSVRF | IPSGAAGSPM | SGNLLVSASR | DKTLRIWDVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TGYCVKTLSG | HVDWVRAVAP | SIDGRFLFAA | GDDRIPRLWD | LSAAETRSTF | LGHEHVIECV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AIAPAASYPH | LAVLSGLKKP | PSASSSAEFF | ATGSRDKTIR | LWDSRGNLIK | TLVGHDNWVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALAFHPGGKY | LLSVSDDKTI | RCWDLTQECK | CVRTIADTHE | HFVTCLRWAP | PLIKDSGANG |
| 430 | 440 | 450 | 460 | ||
| DAGANGTPAA | TTTSNGARQD | PNAANKISIR | CVIATGSVDQ | KVRVFAT |