A1CMQ7

PR
Gene name
sub2 (ACLA_097850)
Protein name
ATP-dependent RNA helicase sub2
Names
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
KEGG Pathway
act:ACLA_097850
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1CMQ7

Entry ID Method Resolution Chain Position Source
AF-A1CMQ7-F1 Predicted AlphaFoldDB

No variants for A1CMQ7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1CMQ7

No associated diseases with A1CMQ7

4 regional properties for A1CMQ7

Type Name Position InterPro Accession
domain Helicase, C-terminal 276 - 437 IPR001650
domain DEAD/DEAH box helicase domain 83 - 250 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 77 - 280 IPR014001
domain RNA helicase, DEAD-box type, Q motif 58 - 86 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
transcription export complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

6 GO annotations of biological process

Name Definition
mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule.
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
subtelomeric heterochromatin assembly The compaction of chromatin into heterochromatin at the subtelomeric region.
transcription elongation by RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
transcription-coupled nucleotide-excision repair The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSHEEDLIDY SDEELQTTDA AATTAAPAAN GAQDKKGDLT VSGGRPDKKG SYVGIHSTGF
70 80 90 100 110 120
RDFLLKGELL RAITDCGFEH PSEVQQVCIP TAILNVDVLC QAKSGLGKTA VFVLTTLHQL
130 140 150 160 170 180
EPVPGECSVL VMCHTRELAY QIKNEYARFS KYLPDVKTAV FYGGTPIQKD VEVLSNKESY
190 200 210 220 230 240
PNIVVGTPGR LNALVRDKKL SLRNVKAFVL DECDKMLDQI DMRRDVQEIF RATPADKQVM
250 260 270 280 290 300
MFSATLSQEI RPICKKFMRN PLEVYVDDDT KLTLHGLQQY YIKLSESEKN RKLNELLDSL
310 320 330 340 350 360
EFNQVIIFVK STLRANELDK LLRECNFPSI AVHSGVSQEE RIKRYKEFKE FNKRICVATD
370 380 390 400 410 420
VFGRGIDIER INLAINYDLP ADADSYLHRV GRAGRFGTKG LSISFVSNED DEKVLKEIEK
430 440
RFEVALPEYP EGGVDSSTYM A