A1CLD7

PR
Gene name
guf1 (ACLA_041830)
Protein name
Translation factor guf1, mitochondrial
Names
Elongation factor 4 homolog, EF-4, GTPase guf1, Ribosomal back-translocase
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
KEGG Pathway
act:ACLA_041830
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1CLD7

Entry ID Method Resolution Chain Position Source
AF-A1CLD7-F1 Predicted AlphaFoldDB

No variants for A1CLD7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1CLD7

No associated diseases with A1CLD7

2 regional properties for A1CLD7

Type Name Position InterPro Accession
domain IMP dehydrogenase/GMP reductase 8 - 317 IPR001093
conserved_site IMP dehydrogenase / GMP reductase, conserved site 166 - 178 IPR015875

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
mitochondrial ribosome binding Binding to a mitochondrial ribosome.

2 GO annotations of biological process

Name Definition
positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGCLQLARW LSAAPKGTAA SLTRAPFGLA NATRFFTNSA ARAGSRATAS KPVTDLENRI
70 80 90 100 110 120
SAIPIERYRN FCIVAHVDHG KSTLSDRLLE LTGTIQPGSN KQVLDKLDVE RERGITVKAQ
130 140 150 160 170 180
TCTMIYNHNG EDYLLHLVDT PGHVDFRAEV SRSYASCGGA LLLVDASQGV QAQTVANFYL
190 200 210 220 230 240
AFAQGLELIP VINKVDLPSA EPQRALDQMK HTFELDTENA VMVSAKTGLN VEQLLPTVVD
250 260 270 280 290 300
KIPAPIGDCK KPLRMLLVDS WYDSYKGVIC LVRIFDGELR AGQQVVSFAT GLKYYVGEVG
310 320 330 340 350 360
IMYPNETAQS VIRAGQVGYI YFNPGMKRSQ EAKIGDTFTK VGSEKAVQPL PGFEEPKAMV
370 380 390 400 410 420
FVAAYPVDAD HFEHLEDSIN QLVLNDRSIT VQKESSEALG AGFRLGFLGT LHCSVFEDRL
430 440 450 460 470 480
RQEHGASIII TPPSVPVKVI WTDGKEEIIT SPVRFPDDEE VRNKIAEIQE PYVLATLTFP
490 500 510 520 530 540
EEYLGKVIEL CEANRGEQKT LEYFTATQVI LKYELPLAQL VDDFFGKLKG STKGYASLDY
550 560 570 580 590 600
EESAWQPGHI VKLQLLVNKA PVDAVARIMH SSQVDRLARQ WVTKFKQHVD RQLFEVVIQA
610 620 630 640 650 660
AVGRKVIARE TVKPYRKDVL AKLHASDVSR RRKLLEKQKE GRKRLRAVGN VVIEHKAFQA
FLAK