A1CKN5

PR
Gene name
get3 (ACLA_039240)
Protein name
ATPase get3
Names
Arsenical pump-driving ATPase, Arsenite-stimulated ATPase, Golgi to ER traffic protein 3, Guided entry of tail-anchored proteins 3
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
KEGG Pathway
act:ACLA_039240
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1CKN5

Entry ID Method Resolution Chain Position Source
AF-A1CKN5-F1 Predicted AlphaFoldDB

No variants for A1CKN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1CKN5

No associated diseases with A1CKN5

3 regional properties for A1CKN5

Type Name Position InterPro Accession
domain Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic 20 - 314 IPR006075
conserved_site Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site 165 - 179 IPR017958
domain Asn/Gln amidotransferase 352 - 499 IPR018027

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.
protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process.
unfolded protein binding Binding to an unfolded protein.

6 GO annotations of biological process

Name Definition
pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
post-translational protein targeting to endoplasmic reticulum membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.
protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSAAVVHHD DLMEPTLQSI INQKTLRWIF VGGKGGVGKT TTSCSLAIQL AKARKSVLLI
70 80 90 100 110 120
STDPAHNLSD AFGQKFGKEA RLVDGYSNLS AMEIDPNGSI QDLLASGEAQ GEDPMAGLGM
130 140 150 160 170 180
GNMMQDLAFS IPGVDEAMSF AEVLKQVKSL SYEVIVFDTA PTGHTLRFLQ FPTVLEKALA
190 200 210 220 230 240
KLSQLSSQFG PMLNSILGAR GGLPGGQNID ELLQKMESLR ETISEVNTQF KNPDMTTFVC
250 260 270 280 290 300
VCIAEFLSLY ETERMIQELT SYSIDTHAIV VNQLLFPKKG SECEQCNARR KMQQKYLEQI
310 320 330
EELYEDFNVV RMPLLVEEVR GKEKLEKFSE MLVHPYVPPQ