A1C7R6

PR
Gene name
ssn8 (ACLA_074740)
Protein name
RNA polymerase II holoenzyme cyclin-like subunit
Names
Species
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
KEGG Pathway
act:ACLA_074740
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

184-275 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1C7R6

Entry ID Method Resolution Chain Position Source
AF-A1C7R6-F1 Predicted AlphaFoldDB

No variants for A1C7R6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1C7R6

No associated diseases with A1C7R6

2 regional properties for A1C7R6

Type Name Position InterPro Accession
domain NADPH-dependent FMN reductase-like 4 - 143 IPR005025
domain Flavodoxin/nitric oxide synthase 4 - 189 IPR008254

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAANYWASTQ RRHWLFTRER LAEIREAFRE RHKLAHSQFP LPDQRLLNIY FSQQLIKLGK
70 80 90 100 110 120
RMSTRQQALA TAQVYIKRFY TKNEIRHTNP YLVLTTAFYL ACKMEECPQH IRFVVGEARS
130 140 150 160 170 180
LWPEFITPDV SKLGECEFSL ISEMNSQLIV HHPYRTLSGL QSELSLTSDE VALAWSVIND
190 200 210 220 230 240
HYLTDLPLLY SPHVIAVMAV MVAVVFKPGP GNFHGSAAPV LAGAMRDGGM NMLAALGDKS
250 260 270 280 290 300
GNEPPPKVQK LINWLAESEV DIKAVIECTQ ELVSLYEVWE QYSEKNCKEL LGRMVKTKHL
DK