A1AAE2

PR
Gene name
kdsA
Protein name
2-dehydro-3-deoxyphosphooctonate aldolase
Names
3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase
Species
Escherichia coli O1:K1 / APEC
KEGG Pathway
ecv:APECO1_332
EC number
2.5.1.55: Transferring alkyl or aryl groups, other than methyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

177-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1AAE2

Entry ID Method Resolution Chain Position Source
AF-A1AAE2-F1 Predicted AlphaFoldDB

No variants for A1AAE2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1AAE2

No associated diseases with A1AAE2

1 regional properties for A1AAE2

Type Name Position InterPro Accession
domain DAHP synthetase I/KDSA 10 - 274 IPR006218

Functions

Description
EC Number 2.5.1.55 Transferring alkyl or aryl groups, other than methyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
3-deoxy-8-phosphooctulonate synthase activity Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKQKVVSIGD INVANDLPFV LFGGMNVLES RDLAMRICEH YVTVTQKLGI PYVFKASFDK
70 80 90 100 110 120
ANRSSIHSYR GPGLEEGMKI FQELKQTFGV KIITDVHEPS QAQPVADVVD VIQLPAFLAR
130 140 150 160 170 180
QTDLVEAMAK TGAVINVKKP QFVSPGQMGN IVDKFKEGGN EKVILCDRGA NFGYDNLVVD
190 200 210 220 230 240
MLGFSIMKKV SGNSPVIFDV THALQCRDPF GAASGGRRAQ VAELARAGMA VGLAGLFIEA
250 260 270 280
HPDPEHAKCD GPSALPLAKL EPFLKQMKAI DDLVKGFEEL DTSK