AiPD: Autoinhibited Protein Database

A1A4Y4

Gene name	IRGM (IFI1, IRGM1, LRG47)
Protein name	Immunity-related GTPase family M protein
Names	Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47
Species	Homo sapiens (Human)
KEGG Pathway	hsa:345611
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-96 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for A1A4Y4

Entry ID	Method	Resolution	Chain	Position	Source
AF-A1A4Y4-F1	Predicted				AlphaFoldDB

170 variants for A1A4Y4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1322402828 CA361784797	2	E>*		No	ClinGen gnomAD
CA361784795 rs1322402828	2	E>K		No	ClinGen gnomAD
rs763474099 CA129176681	3	A>T		No	ClinGen TOPMed gnomAD
rs749790081 CA3515024	3	A>V		No	ClinGen ExAC gnomAD
CA361784810 rs1336743456	4	M>T		No	ClinGen gnomAD
CA129176685 rs1040621750	4	M>V		No	ClinGen Ensembl
rs1193048835 CA361784817	5	N>H		No	ClinGen TOPMed gnomAD
CA361784833 rs1561738640	7	E>G		No	ClinGen Ensembl
CA361784841 rs1407543289	8	K>R		No	ClinGen gnomAD
rs757815291 CA3515025	9	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1020331668 CA129176700	11	A>E		No	ClinGen gnomAD
CA3515027 VAR_039899 CA361784902 rs180802994	17	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD UniProt dbSNP
rs1189533418 CA361784900	17	E>G		No	ClinGen gnomAD
CA361784903 rs1457946148	18	V>M		No	ClinGen TOPMed gnomAD
rs1159661553 CA361784920	20	S>C		No	ClinGen gnomAD
CA361784924 rs1390516945	21	N>D		No	ClinGen TOPMed gnomAD
rs1390516945 CA361784923	21	N>Y		No	ClinGen TOPMed gnomAD
TCGA novel	22	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1034089597 CA129176719	22	I>V		No	ClinGen gnomAD
CA361784939 rs1322491414	23	K>R		No	ClinGen TOPMed
TCGA novel	24	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1317484762 CA361784948	24	E>G		No	ClinGen gnomAD
CA361784944 rs1378941541	24	E>K		No	ClinGen TOPMed gnomAD
rs1438074567 CA361784954	25	T>P		No	ClinGen gnomAD
CA361784961 rs1228567208	26	L>P		No	ClinGen gnomAD
rs139363001 CA129176726	27	K>N		No	ClinGen 1000Genomes
CA361784976 rs1327432426	28	I>M		No	ClinGen gnomAD
rs1290629133 CA361784974	28	I>T		No	ClinGen gnomAD
rs994846114 CA129176757	33	P>A		No	ClinGen TOPMed
rs994846114 CA129176753	33	P>T		No	ClinGen TOPMed
CA361785006 rs1377693714	34	V>I		No	ClinGen TOPMed
TCGA novel	37	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA361785032 rs1268209168	37	T>I		No	ClinGen gnomAD
CA361785034 rs1473059816	38	M>V		No	ClinGen TOPMed gnomAD
CA361785045 rs1184533557	39	A>E		No	ClinGen gnomAD
CA361785058 rs1157782183	41	D>G		No	ClinGen gnomAD
rs1561738748 CA361785056	41	D>Y		No	ClinGen Ensembl
rs962229683 CA129176766	42	S>A		No	ClinGen Ensembl
rs1581637754 CA361785079	44	N>K		No	ClinGen Ensembl
CA361785077 rs1414501331	44	N>S		No	ClinGen TOPMed gnomAD
CA361785091 rs1189812480	46	M>T		No	ClinGen TOPMed
CA129176770 rs1027625080	48	T>A		No	ClinGen Ensembl
CA3515031 rs779184883	48	T>I		No	ClinGen ExAC TOPMed gnomAD
CA361785104 rs779184883	48	T>N		No	ClinGen ExAC TOPMed gnomAD
CA3515032 rs187395700	51	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA129176782 rs187395700	51	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA129176788 rs187395700	51	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1581637766 CA361785130	52	A>G		No	ClinGen Ensembl
TCGA novel	53	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA3515033 rs762970800	54	R>*		No	ClinGen ExAC TOPMed gnomAD
CA129176804 COSM1595125 rs930645632	54	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1050494429 CA129176820	56	T>I		No	ClinGen TOPMed gnomAD
rs1050494429 CA129176815	56	T>R		No	ClinGen TOPMed gnomAD
rs1299643610 CA361785156	57	G>E		No	ClinGen TOPMed
rs528514907 CA129176830	58	H>Q		No	ClinGen Ensembl
rs564391527 CA3515035	58	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs759212417 CA3515036	59	E>K		No	ClinGen ExAC gnomAD
rs181858503 CA3515037	60	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1227064665 CA361785175	60	G>D		No	ClinGen gnomAD
rs181858503 CA361785173	60	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA361785185 rs1477282413	62	A>T		No	ClinGen gnomAD
rs1263237930 CA361785188	62	A>V		No	ClinGen Ensembl
rs1249976416 CA361785195	63	S>*		No	ClinGen TOPMed gnomAD
CA361785196 rs1249976416	63	S>L		No	ClinGen TOPMed gnomAD
CA361785192 rs1207370151	63	S>P		No	ClinGen gnomAD
rs1010273904 CA361785201	64	P>L		No	ClinGen gnomAD
rs1010273904 CA129176875	64	P>R		No	ClinGen gnomAD
CA361785199 rs1437434829	64	P>S		No	ClinGen gnomAD
CA361785207 rs1473752726	65	P>L		No	ClinGen gnomAD
CA361785202 rs1237785008	65	P>S		No	ClinGen gnomAD
CA129176897 rs913219331	66	T>A		No	ClinGen TOPMed gnomAD
CA361785243 rs551248565	71	A>D		No	ClinGen 1000Genomes gnomAD
TCGA novel	71	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA129176902 rs551248565	71	A>V		No	ClinGen 1000Genomes gnomAD
CA3515040 rs563186745	73	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1169723689 CA361785258	74	R>G		No	ClinGen TOPMed
rs1290993470 CA361785264	74	R>S		No	ClinGen gnomAD
rs1043976431 CA129176906	76	A>V		No	ClinGen gnomAD
CA129176908 rs904216759	77	S>F		No	ClinGen TOPMed gnomAD
CA361785289 rs1451113614	78	Y>*		No	ClinGen gnomAD
rs978814079 CA129176911	78	Y>C		No	ClinGen TOPMed gnomAD
rs1554126690 CA361785303	80	S>F		No	ClinGen Ensembl
CA129176917 rs925151384	82	H>Y		No	ClinGen TOPMed gnomAD
rs1230759009 CA361785328	84	S>*		No	ClinGen gnomAD
CA129176919 rs748507126	85	N>D		No	ClinGen Ensembl
CA129176925 rs999847831	85	N>S		No	ClinGen Ensembl
rs530731715 CA129176928	86	V>M		No	ClinGen 1000Genomes
CA361785342 rs936462559	87	V>L		No	ClinGen TOPMed
CA129176932 rs936462559	87	V>M		No	ClinGen TOPMed
CA129176940 rs781556508	88	L>V		No	ClinGen Ensembl
rs1275516308 CA361785358	89	W>L		No	ClinGen TOPMed
CA361785364 rs1581637909	90	D>A		No	ClinGen Ensembl
CA3515041 rs753392162	90	D>N		No	ClinGen ExAC gnomAD
CA361785363 rs753392162	90	D>Y		No	ClinGen ExAC gnomAD
rs1358694005 CA361785383	92	P>L		No	ClinGen TOPMed
rs1325800218 CA361785379	92	P>S		No	ClinGen TOPMed gnomAD
CA361785401 rs72553867	94	T>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_039900 CA3515042 rs72553867	94	T>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA361785414 rs1449969231	96	S>P		No	ClinGen gnomAD
CA3515044 rs750960300	97	A>P		No	ClinGen ExAC TOPMed gnomAD
CA361785423 rs750960300	97	A>S		No	ClinGen ExAC TOPMed gnomAD
rs1561738938 CA361785427	97	A>V		No	ClinGen Ensembl
CA361785429 rs1561738941	98	T>S		No	ClinGen Ensembl
CA129176962 rs1024182878	98	T>S		No	ClinGen TOPMed gnomAD
rs1172742457 CA361785447	100	T>A		No	ClinGen gnomAD
rs758635688 CA3515045	100	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	102	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468633505 CA361785472	102	E>G		No	ClinGen gnomAD
rs1199734968 CA361785466	102	E>K		No	ClinGen TOPMed gnomAD
rs1336452787 CA361785487	103	N>S		No	ClinGen gnomAD
rs972416559 CA129176974	104	Y>*		No	ClinGen gnomAD
CA361785507 rs10065172	105	L>M	Inflammatory bowel disease 19 (ibd19) [Ensembl]	No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747196011 CA3515046	105	L>P		No	ClinGen ExAC gnomAD
rs769060814 CA3515047	108	M>V		No	ClinGen ExAC gnomAD
CA129176982 rs1026652178	112	R>Q		No	ClinGen TOPMed gnomAD
rs781399456 CA3515048	112	R>W		No	ClinGen ExAC TOPMed gnomAD
CA129176988 rs888198292	113	Y>C		No	ClinGen TOPMed gnomAD
rs1262253413 CA361785632	115	F>L		No	ClinGen gnomAD
CA361785642 rs1473718690	116	I>L		No	ClinGen TOPMed
rs1465308333 CA361785669	118	V>I		No	ClinGen TOPMed gnomAD
rs1465308333 CA361785671	118	V>L		No	ClinGen TOPMed gnomAD
rs1259073219 CA361785699	120	S>F		No	ClinGen gnomAD
rs1425162166 CA361785711	122	Q>*		No	ClinGen gnomAD
rs72553868 CA3515050	124	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1356724715 CA361785742	124	S>I		No	ClinGen TOPMed
rs1356724715 CA361785744	124	S>N		No	ClinGen TOPMed
rs72553868 CA129176992	124	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA129176999 rs910643430	125	M>I		No	ClinGen Ensembl
rs998415796 CA129177006	126	N>H		No	ClinGen TOPMed
rs774097437 CA3515051	126	N>S		No	ClinGen ExAC gnomAD
CA361785782 rs1479241391	127	H>R		No	ClinGen gnomAD
rs1288606899 CA361785778	127	H>Y		No	ClinGen TOPMed
rs1403723829 CA361785810	129	M>I		No	ClinGen TOPMed
CA361785814 rs1176193689	130	L>F		No	ClinGen TOPMed gnomAD
rs944754177 CA129177013	132	K>E		No	ClinGen gnomAD
CA129177015 rs1020311575	133	T>A		No	ClinGen TOPMed gnomAD
rs1384852901 CA361785839 COSM1567828	134	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA3515053 rs771760057	137	M>V		No	ClinGen ExAC gnomAD
CA361785872 rs1343923577	138	G>V		No	ClinGen gnomAD
CA361785880 rs1282432028	139	K>M		No	ClinGen gnomAD
rs1223081022 CA361785875	139	K>Q		No	ClinGen gnomAD
rs1018634990 CA129177043	142	Y>C		No	ClinGen Ensembl
rs1329529820 CA361785908	143	I>V		No	ClinGen gnomAD
rs1217660445 CA361785915	144	V>F		No	ClinGen gnomAD
TCGA novel	145	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA129177047 rs945552191	147	K>T		No	ClinGen Ensembl
rs1270349242 CA361785959	150	M>R		No	ClinGen TOPMed gnomAD
rs1270349242 CA361785958	150	M>T		No	ClinGen TOPMed gnomAD
CA361785965 rs1489736190	151	D>Y		No	ClinGen gnomAD
CA129177063 rs539375226	152	L>P		No	ClinGen 1000Genomes TOPMed gnomAD
rs1247174191 CA361785993	155	G>D		No	ClinGen TOPMed
CA361785997 rs371234734	156	A>S		No	ClinGen TOPMed gnomAD
CA129177067 rs371234734	156	A>T		No	ClinGen TOPMed gnomAD
CA129177073 rs373476641	157	L>F		No	ClinGen gnomAD
rs1222550972 CA361786005	157	L>R		No	ClinGen TOPMed
CA361786002 rs373476641	157	L>V		No	ClinGen gnomAD
rs1225361140 CA361786008	158	P>S		No	ClinGen TOPMed gnomAD
CA3515056 rs763772711	159	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1363769169 CA361786026	161	Q>E		No	ClinGen gnomAD
rs1234599021 CA361786031	161	Q>H		No	ClinGen TOPMed
CA361786036 rs1458848593	162	L>P		No	ClinGen gnomAD
CA361786042 rs1295386241	163	L>P		No	ClinGen gnomAD
CA129177074 rs935668004	164	Q>E		No	ClinGen TOPMed
rs758335779 CA3515057	173	L>F		No	ClinGen ExAC TOPMed gnomAD
CA361786109 rs1352556442	173	L>H		No	ClinGen gnomAD
rs1304567948 CA361786125	175	K>M		No	ClinGen gnomAD
CA3515060 rs764743745	177	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA3515058 rs777611759	177	R>W		No	ClinGen ExAC TOPMed
CA361786148 rs1356574835	179	C>Y		No	ClinGen gnomAD
CA361786165 rs1221079969	181	Y>C		No	ClinGen gnomAD

1 associated diseases with A1A4Y4

[MIM: 612278]: Inflammatory bowel disease 19 (IBD19)

A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:17554261, ECO:0000269|PubMed:19174780, ECO:0000269|PubMed:21278745}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Without disease ID

A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:17554261, ECO:0000269|PubMed:19174780, ECO:0000269|PubMed:21278745}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

1 regional properties for A1A4Y4

Type	Name	Position	InterPro Accession
domain	IRG-type guanine nucleotide-binding (G) domain	32 - 181	IPR030385

Functions

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane Cell membrane Cytoplasmic vesicle, phagosome membrane Cytoplasmic vesicle, autophagosome membrane Lysosome membrane Late endosome membrane Mitochondrion membrane Cell projection, phagocytic cup	Behaves like an integral membrane protein Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent Also detected in late endosomes and lysosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum membrane	The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
phagocytic cup	An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
phagocytic vesicle membrane	The lipid bilayer surrounding a phagocytic vesicle.

6 GO annotations of molecular function

Name	Definition
BH3 domain binding	Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
CARD domain binding	Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine/threonine kinase activator activity	Binds to and increases the activity of a protein serine/threonine kinase.

23 GO annotations of biological process

Name	Definition
autophagosome assembly	The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
CAMKK-AMPK signaling cascade	The series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity.
cellular response to interferon-beta	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
cellular response to lipopolysaccharide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to virus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to Gram-negative bacterium	Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
nucleotide-binding oligomerization domain containing 2 signaling pathway	The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 2 (NOD2) protein receptor, and ending with regulation of a downstream cellular process.
positive regulation of autophagosome maturation	Any process that activates or increases the frequency, rate or extent of autophagosome maturation.
positive regulation of autophagy	Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
positive regulation of interferon-gamma-mediated signaling pathway	Any process that increases the rate, frequency or extent of an interferon-gamma-mediated signaling pathway.
positive regulation of peptidyl-serine phosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
positive regulation of peptidyl-threonine phosphorylation	Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of protein serine/threonine kinase activity	Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
protein destabilization	Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
protein lipidation involved in autophagosome assembly	The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of protein complex stability	Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.
regulation of protein-containing complex assembly	Any process that modulates the frequency, rate or extent of protein complex assembly.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MEAMNVEKAS	ADGNLPEVIS	NIKETLKIVS	RTPVNITMAG	DSGNGMSTFI	SALRNTGHEG
70	80	90	100	110	120
KASPPTELVK	ATQRCASYFS	SHFSNVVLWD	LPGTGSATTT	LENYLMEMQF	NRYDFIMVAS
130	140	150	160	170	180
AQFSMNHVML	AKTAEDMGKK	FYIVWTKLDM	DLSTGALPEV	QLLQIRENVL	ENLQKERVCE

Y