A1A4K5
PR
Gene name |
ENPP2 |
Protein name |
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Names |
E-NPP 2, Autotaxin, Extracellular lysophospholipase D, LysoPLD |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:532663 |
EC number |
3.1.4.39: Phosphoric diester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1A4K5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1A4K5-F1 | Predicted | AlphaFoldDB |
87 variants for A1A4K5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs459483639 | 2 | A>P | No | EVA | |
| rs470825325 | 3 | R>M | No | EVA | |
| rs457050143 | 11 | Q>H | No | EVA | |
| rs433502443 | 12 | V>G | No | EVA | |
| rs464814239 | 22 | V>F | No | EVA | |
| rs379831057 | 38 | G>V | No | EVA | |
| rs525579588 | 40 | G>D | No | EVA | |
| rs451122163 | 41 | E>D | No | EVA | |
| rs461886379 | 47 | L>F | No | EVA | |
| rs475560077 | 47 | L>V | No | EVA | |
| rs453002513 | 70 | G>R | No | EVA | |
| rs432900428 | 76 | C>F | No | EVA | |
| rs456970801 | 89 | D>A | No | EVA | |
| rs470660151 | 89 | D>Y | No | EVA | |
| rs436794787 | 92 | E>* | No | EVA | |
| rs470369471 | 138 | C>S | No | EVA | |
| rs478270591 | 172 | D>A | No | EVA | |
| rs446901287 | 172 | D>Y | No | EVA | |
| rs444329982 | 173 | G>D | No | EVA | |
| rs461822721 | 188 | N>K | No | EVA | |
| rs41743834 | 190 | E>K | No | EVA | |
| rs442659406 | 211 | F>L | No | EVA | |
| rs464493677 | 223 | P>A | No | EVA | |
| rs450856635 | 228 | I>N | No | EVA | |
| rs437172197 | 236 | P>L | No | EVA | |
| rs468567172 | 238 | F>V | No | EVA | |
| rs468476605 | 263 | T>A | No | EVA | |
| rs441730874 | 279 | V>G | No | EVA | |
| rs463317949 | 295 | L>P | No | EVA | |
| rs456449095 | 309 | E>K | No | EVA | |
| rs437000811 | 361 | G>R | No | EVA | |
| rs446749695 | 374 | S>G | No | EVA | |
| rs436292195 | 452 | W>* | No | EVA | |
| rs444394784 | 520 | K>Q | No | EVA | |
| rs474187205 | 539 | T>P | No | EVA | |
| rs439229609 | 573 | A>V | No | EVA | |
| rs799805225 | 586 | L>F | No | EVA | |
| rs450749718 | 628 | A>S | No | EVA | |
| rs475283937 | 630 | L>I | No | EVA | |
| rs480599701 | 647 | Y>* | No | EVA | |
| rs468566927 | 648 | S>G | No | EVA | |
| rs446819985 | 648 | S>N | No | EVA | |
| rs479674115 | 649 | E>Q | No | EVA | |
| rs446786545 | 670 | I>V | No | EVA | |
| rs469442705 | 684 | V>I | No | EVA | |
| rs521288128 | 695 | Y>C | No | EVA | |
| rs478292345 | 713 | S>* | No | EVA | |
| rs458302359 | 714 | S>F | No | EVA | |
| rs448075669 | 773 | D>E | No | EVA | |
| rs459281220 | 775 | Q>E | No | EVA | |
| rs456628895 | 781 | Y>D | No | EVA | |
| rs474451696 | 785 | S>G | No | EVA | |
| rs455996605 | 785 | S>T | No | EVA | |
| rs434274641 | 787 | V>A | No | EVA | |
| rs447221626 | 791 | T>P | No | EVA | |
| rs439327714 | 797 | L>V | No | EVA | |
| rs465073262 | 798 | T>P | No | EVA | |
| rs449750646 | 804 | T>P | No | EVA | |
| rs461139198 | 806 | P>H | No | EVA | |
| rs461139198 | 806 | P>L | No | EVA | |
| rs477143166 | 807 | A>V | No | EVA | |
| rs135589351 | 808 | D>A | No | EVA | |
| rs449180113 | 808 | D>Y | No | EVA | |
| rs460496009 | 811 | D>V | No | EVA | |
| rs438826105 | 814 | L>P | No | EVA | |
| rs463049595 | 823 | H>P | No | EVA | |
| rs474399155 | 826 | D>A | No | EVA | |
| rs455882552 | 828 | D>H | No | EVA | |
| rs455882552 | 828 | D>Y | No | EVA | |
| rs434211517 | 829 | E>G | No | EVA | |
| rs473514936 | 830 | S>I | No | EVA | |
| rs472760431 | 841 | V>G | No | EVA | |
| rs432638727 | 844 | L>I | No | EVA | |
| rs465682226 | 848 | H>Q | No | EVA | |
| rs436780130 | 850 | A>P | No | EVA | |
| rs448064716 | 851 | R>G | No | EVA | |
| rs480937222 | 852 | V>G | No | EVA | |
| rs447400312 | 854 | D>A | No | EVA | |
| rs458837897 | 857 | H>D | No | EVA | |
| rs443535021 | 862 | D>A | No | EVA | |
| rs476622903 | 863 | F>S | No | EVA | |
| rs461368151 | 864 | F>S | No | EVA | |
| rs442913534 | 867 | T>P | No | EVA | |
| rs472698163 | 871 | Y>H | No | EVA | |
| rs432557344 | 880 | Y>* | No | EVA | |
| rs454275487 | 880 | Y>F | No | EVA | |
| rs876137431 | 885 | E>G | No | EVA |
No associated diseases with A1A4K5
7 regional properties for A1A4K5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Somatomedin B domain | 55 - 98 | IPR001212-1 |
| domain | Somatomedin B domain | 99 - 143 | IPR001212-2 |
| domain | DNA/RNA non-specific endonuclease | 638 - 870 | IPR001604 |
| domain | Somatomedin B domain, chordata | 54 - 67 | IPR020436-1 |
| domain | Somatomedin B domain, chordata | 72 - 83 | IPR020436-2 |
| domain | Somatomedin B domain, chordata | 84 - 95 | IPR020436-3 |
| domain | Extracellular Endonuclease, subunit A | 640 - 870 | IPR020821 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.4.39 | Phosphoric diester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| alkylglycerophosphoethanolamine phosphodiesterase activity | Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| dinucleotide phosphatase activity | Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. |
| lysophospholipase activity | Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
| nucleic acid binding | Binding to a nucleic acid. |
| phosphodiesterase I activity | Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. |
| polysaccharide binding | Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. |
| scavenger receptor activity | Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). |
| zinc ion binding | Binding to a zinc ion (Zn). |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| chemotaxis | The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| estrous cycle | A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. |
| immune response | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. |
| phosphatidylcholine catabolic process | The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| phospholipid catabolic process | The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
| positive regulation of epithelial cell migration | Any process that activates or increases the frequency, rate or extent of epithelial cell migration. |
| positive regulation of lamellipodium morphogenesis | Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. |
| positive regulation of peptidyl-tyrosine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| regulation of angiogenesis | Any process that modulates the frequency, rate or extent of angiogenesis. |
| sphingolipid catabolic process | The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARRRSCQLH | QVISLFTFAV | GVNICLGVTA | NRIKRAEGWG | EGPPTVLSDS | PSINISGSCK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRCFELQEAG | PPDCRCDNLC | KSYSSCCLDF | DELCLKTAGG | WECTKDRCGE | VRNEDHACHC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SEDCLARGDC | CTNYQVVCKG | ESHWVDDDCE | EIKTPECPAG | FVRPPLIIFS | VDGFRASYMK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KGSKVMPNIE | KLRSCGTHSP | YMRPVYPTKT | FPNLYTLATG | LYPESHGIVG | NSMYDPVFDA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HFNLRGREKF | NHRWWGGQPL | WITATKQGVI | AGTFFWPVVI | PHERRILTIL | QWLTLPDHER |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSVYAFYSEQ | PDFSGHKYGP | FGPEMTNPLR | DIDKTVGQLM | DGLKQLKLHR | CVNVIFVGDH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GMEDVTCDRT | EFLSNYLTNV | DDIILVPGTL | GRIRPKFNNH | AKYDPKVIIA | NLTCKKPDQH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FKPYLKQHLP | KRLHYANNRR | IEDVHLLVER | RWHVARKPLE | VYKKPSGKCF | FQGDHGFDNK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNSMQTVFVG | YGPTFKYKTK | VPPFENIELY | NVMCDLLGLK | PAPNNGTHGS | LNHLLRTNTF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RPTVPEEVTR | PNYPGVMYLQ | SDFDLGCTCD | DKAEPKNKLD | ELNKHLHIKE | STEAETRKFR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GSKNEIKENV | NGNFEPRKER | HLLYGRPAVL | YRTRYDILYH | TDFESGYSEI | FLMPLWTSYT |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VSKQADVSDI | PAHLTNCVRP | DVRVSPSFSQ | SCLAYKNDKQ | MSYGFLFPPY | LSSSPEAKYD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AFLVTNMVPM | YPAFKRIWNY | FQRVLVKKYA | SERNGVNVIS | GPIFDYDYDG | LHDTQDKIKQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| YVEGSSVPVP | THYYSILTSC | LDFTQPADRC | DGPLSVSAFV | LPHRPDNDES | CNSSEDESKW |
| 850 | 860 | 870 | 880 | ||
| VEELLKMHTA | RVRDIEHLTS | LDFFRKTSRS | YPEILTLKTY | LQTYESEI |