A1A2H6

PR
Gene name
hisC
Protein name
Histidinol-phosphate aminotransferase
Names
Imidazole acetol-phosphate transaminase
Species
Bifidobacterium adolescentis (strain ATCC 15703 / DSM 20083 / NCTC 11814 / E194a)
KEGG Pathway
bad:BAD_1128
EC number
2.6.1.9: Transaminases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1A2H6

Entry ID Method Resolution Chain Position Source
AF-A1A2H6-F1 Predicted AlphaFoldDB

No variants for A1A2H6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1A2H6

No associated diseases with A1A2H6

2 regional properties for A1A2H6

Type Name Position InterPro Accession
binding_site Aminotransferase, class-II, pyridoxal-phosphate binding site 242 - 251 IPR001917
domain Aminotransferase, class I/classII 36 - 381 IPR004839

Functions

Description
EC Number 2.6.1.9 Transaminases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSETSSNAIP AYLPLRNDLI GEEPYGAPQL DVPVCLNVNE NPYAPEPAVV ETIAQRVKEI
70 80 90 100 110 120
APTLNRYPDR EHIELRKAFS TYLERESGVK LSVDQLWGAN GSNEIMLQLF QAFGGPGRIA
130 140 150 160 170 180
LGCDPTYSMY PEYARDTFTT WKLAHRNADF TLDVDATIKA IEDVKPAMIV LTSPNNPTGT
190 200 210 220 230 240
PLKPEDLKRV LEAARTAEVA GAAEGVHPVV VVDEAYIEFR DPGTPTALEL IGEYENLAVS
250 260 270 280 290 300
RTMSKAFAFA GARVGYLAAN KGIIDCVRIV RMPYHLSAVT QAAALAAFEH TDEQLSRVAH
310 320 330 340 350 360
LRETRNATSA WLKEQTYKGQ PLEVAETQSN FILFGGHFDD RDRIFDELLK RGVLIRVVGP
370 380 390
EGWMRVCMGT DEEMARFREA LVEVLRIVEQ G