A0R8H2
Gene name |
rpoB |
Protein name |
DNA-directed RNA polymerase subunit beta |
Names |
RNAP subunit beta, RNA polymerase subunit beta, Transcriptase subunit beta |
Species |
Bacillus thuringiensis (strain Al Hakam) |
KEGG Pathway |
btl:BALH_0100 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0R8H2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0R8H2-F1 | Predicted | AlphaFoldDB |
No variants for A0R8H2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0R8H2 | |||||
No associated diseases with A0R8H2
8 regional properties for A0R8H2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA-directed RNA polymerase, subunit 2, hybrid-binding domain | 675 - 1068 | IPR007120 |
| conserved_site | RNA polymerase, beta subunit, conserved site | 921 - 933 | IPR007121 |
| domain | RNA polymerase Rpb2, domain 7 | 1070 - 1145 | IPR007641 |
| domain | RNA polymerase Rpb2, domain 2 | 140 - 290 | IPR007642-1 |
| domain | RNA polymerase Rpb2, domain 2 | 373 - 409 | IPR007642-2 |
| domain | RNA polymerase, beta subunit, protrusion | 28 - 453 | IPR007644 |
| domain | RNA polymerase Rpb2, domain 3 | 468 - 536 | IPR007645 |
| domain | DNA-directed RNA polymerase, beta subunit, external 1 domain | 546 - 613 | IPR019462 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| ribonucleoside binding | Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTGQLVQYGR | HRQRRSYARI | SEVLELPNLI | EIQTSSYQWF | LDEGLREMFQ | DISPIEDFTG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NLSLEFIDYS | LGEPKYSVDE | CKERDVTYAA | PLRVKVRLIN | KETGEVKEQD | VFMGDFPLMT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETGTFVINGA | ERVIVSQLVR | SPSVYYSGKV | DKNGKRGFTA | TVIPNRGAWL | EYETDAKDVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YVRIDRTRKL | PVTVLLRALG | FGSDQEITEL | LGDNEYLSNT | LEKDNTDSTE | KALLEIYERL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RPGEPPTVEN | AKSLLVSRFF | DPKRYDLANV | GRYKINKKLH | IKNRLFNQRL | AETLVDPETG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EILAAEGTIL | DRRTLDRILP | YLEKNIGFKT | AKPMGGVVEG | DVELQSIKIY | APESEGERVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NVIGNANITR | DVKHITPGDI | LASISYFFNL | LYKVGDTDDI | DHLGNRRLRS | VGELLQNQFR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IGLSRMERVV | RERMSIQDTN | AITPQALINI | RPVIASIKEF | FGSSQLSQFM | DQTNPLAELT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HKRRLSALGP | GGLTRERAGF | EVRDVHYSHY | GRMCPIETPE | GPNIGLINSL | SSFAKVNEFG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FIETPYRRVD | PETGLVTGHV | DYLTADEEDN | YVVAQANMKL | SEEGEFLDED | IVARFRGENI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VTNKERIDYM | DVSPKQVVSA | ATACIPFLEN | DDSNRALMGA | NMQRQAVPLM | NPESPIVGTG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MEYVSAKDSG | AAVICKHPGI | VERVEAREVW | VRRYVEVDGQ | TVKGDLDRYK | MQKFIRSNQG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TCYNQRPIVS | VGNEVVKGEI | LADGPSMELG | ELALGRNVLV | GFMTWDGYNY | EDAIIMSERL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VKDDVYTSIH | IEEYESEARD | TKLGPEEITR | DIPNVGEDAL | RNLDERGIIR | VGAEVKDGDL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LVGKVTPKGV | TELTAEERLL | HAIFGEKARE | VRDTSLRVPH | GGGGIILDVK | VFNREDGDEL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| PPGVNQLVRA | YIVQKRKISE | GDKMAGRHGN | KGVISRILPE | EDMPYLPDGT | PIDIMLNPLG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VPSRMNIGQV | LELHLGMAAR | YLGIHIATPV | FDGAREEDVW | GTIEEAGMAN | DAKTILYDGR |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TGEPFDNRVS | VGVMYMIKLA | HMVDDKLHAR | STGPYSLVTQ | QPLGGKAQFG | GQRFGEMEVW |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| ALEAYGAAYT | LQEILTVKSD | DVVGRVKTYE | AIVKGENVPE | PGVPESFKVL | IKELQSLGMD |
| 1150 | 1160 | 1170 | |||
| VKMMSSDDTE | IEMRDTEDDD | DHQSADKLNV | EVETTKE |