A0QNL1
Gene name |
mycP1 (MSMEG_0083, MSMEI_0081) |
Protein name |
Mycosin-1 |
Names |
EC 3.4.21.- , MycP1 protease |
Species |
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) |
KEGG Pathway |
msg:MSMEI_0081, msm:MSMEG_0083, |
EC number |
3.4.21.-: Serine endopeptidases |
Protein Class |
PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED (PTHR42884) |
Descriptions
Mycosin-1 protease (MycP1) is a serine protease anchored to the inner membrane of Mycobacterium smegmatis, and is essential in virulence factor secretion through the ESX-1 type VII secretion system (T7SS). MycP1's autoinhibition involves a putative propeptide that wraps around the protease domain in a non-classical manner. Although not directly inhibiting proteolytic activity, the propeptide contributes to conformational stability of the active site, influencing MycP1's function.
Autoinhibitory domains (AIDs)
Target domain |
66-389 (Protease domain) |
Relief mechanism |
|
Assay |
Structural analysis, Deletion assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for A0QNL1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4J94 | X-ray | 186 A | A | 24-407 | PDB |
| 4KB5 | X-ray | 215 A | A | 24-422 | PDB |
| 4KPG | X-ray | 215 A | A | 24-407 | PDB |
| 4M1Z | X-ray | 225 A | PDB | ||
| AF-A0QNL1-F1 | Predicted | AlphaFoldDB |
No variants for A0QNL1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0QNL1 | |||||
No associated diseases with A0QNL1
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.21.- | Serine endopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | PTHR42884 | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED |
| PANTHER Subfamily | PTHR42884:SF14 | NEUROENDOCRINE CONVERTASE 1 |
| PANTHER Protein Class |
serine protease
protein modifying enzyme |
|
| PANTHER Pathway Category |
Endothelin signaling pathway furin Alzheimer disease-presenilin pathway Furin Alzheimer disease-amyloid secretase pathway Furin |
|
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| serine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQRVAVMVLA | VLLALFSAPP | AWAIDPPVID | AGAVPPDETG | PDQPTEQRKI | CATPTVMPNS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NFADRPWAND | YLRIQEAQKF | ATGAGVTVAV | IDTGVNGSPR | VPAEPGGDFV | DAAGNGMSDC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DAHGTMTAAI | IGGRPSPTDG | FVGMAPDVRL | LSLRQTSVAF | QPKGARQDPN | DPNTTQTAGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IRSLARSVVH | AANLGAQVIN | ISEAACYKVT | RRIDETSLGA | AINYAVNVKG | AVIVVAAGNT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GQDCSQNPPP | DPSVPSDPRG | WREVQTIVSP | AWYDPLVLTV | GSIGQNGQPS | NFSMSGPWVG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AAAPGENLTS | LGYDGQPVNA | TPGEDGPVPL | NGTSFSAAYV | SGLAALVKQR | FPDLTPAQII |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NRITATARHP | GGGVDNYVGA | GVIDPVAALT | WEIPDGPEKA | PFRVKEVPPP | VYIPPPDRGP |
| 430 | 440 | ||||
| ITAVVIAGAT | LAFALGIGAL | ARRALRRKQ |