A0QNG1

PR
Gene name
pknB (MSMEG_0028, MSMEI_0031)
Protein name
Serine/threonine-protein kinase PknB
Names
Species
Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis)
KEGG Pathway
msm:MSMEG_0028
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-351 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0QNG1

Entry ID Method Resolution Chain Position Source
AF-A0QNG1-F1 Predicted AlphaFoldDB

No variants for A0QNG1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0QNG1

No associated diseases with A0QNG1

7 regional properties for A0QNG1

Type Name Position InterPro Accession
domain Protein kinase domain 11 - 274 IPR000719
domain PASTA domain 355 - 421 IPR005543-1
domain PASTA domain 422 - 489 IPR005543-2
domain PASTA domain 490 - 556 IPR005543-3
domain PASTA domain 557 - 625 IPR005543-4
active_site Serine/threonine-protein kinase, active site 134 - 146 IPR008271
binding_site Protein kinase, ATP binding site 17 - 40 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

2 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTPQHLSDR YELGEILGFG GMSEVHLARD LRLHRDVAVK VLRADLARDP SFYLRFRREA
70 80 90 100 110 120
QNAAALNHPA IVAVYDTGEA ETPNGPLPYI VMEYVDGVTL RDIVHTDGPI APRRAIEIIA
130 140 150 160 170 180
DACQALNFSH QHGIIHRDVK PANIMISKNN AVKVMDFGIA RALADTGNSV TQTAAVIGTA
190 200 210 220 230 240
QYLSPEQARG ETVDARSDVY SLGCVLYEIL TGEPPFIGDS PVAVAYQHVR EDPVPPSRRH
250 260 270 280 290 300
ADVTPELDAV VLKALAKNPD NRYQTAAEMR ADLIRVHEGQ APDAPKVLTD AERTSMLAAP
310 320 330 340 350 360
PADRAGAATQ DMPVPRPAGY SKQRSTSVAR WLIAVAVLAV LTVVVTVAIN MVGGNPRNVQ
370 380 390 400 410 420
VPDVAEQSAD DAQAALQNRG FKTVIDRQPD NEVPPGLVIG TDPEAGSELG AGEQVTINVS
430 440 450 460 470 480
TGPEQALVPD VAGLTPTQAR QKLKDAGFEK FRESPSPSTP EQKGRVLATN PQANQTAAII
490 500 510 520 530 540
NEITIVVGAG PEDAPVLSCA GQNAESCKAI LAAGGFTNTV VVEVDNPAAA GQVVGTEPAD
550 560 570 580 590 600
GQSVPKDTVI QIRVSKGNQF VMPDLVGQFW SDAYPRLTAL GWTGVLDKGP DVRDSGQRTN
610 620
AVVTQSPSAG TPVNKDAKIT LSFAA