A0Q556

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Francisella tularensis subsp novicida (strain U112)
KEGG Pathway
ftn:FTN_0468
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

508-594 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0Q556

Entry ID Method Resolution Chain Position Source
AF-A0Q556-F1 Predicted AlphaFoldDB

No variants for A0Q556

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0Q556

No associated diseases with A0Q556

8 regional properties for A0Q556

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 11 - 22 IPR001412
domain tRNA-binding domain 573 - 673 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 539 - 673 IPR004495
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 411 - 511 IPR013155
domain Methionyl/Leucyl tRNA synthetase 4 - 393 IPR015413
domain Methioninyl-tRNA synthetase core domain 3 - 368 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 381 - 392 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 371 - 503 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRKILVTNAL PYANGDLHLG HMLGYIQSDI WVRFQKLQGN QCIFVCGSDT HGTPIMLKAK
70 80 90 100 110 120
SLGITPEELV TKYSNRHLQD FTDFEINFDN YHSTHNSLNK EIVEDIYNKL NNKNLISKKA
130 140 150 160 170 180
IAQAYDPEAK MFLPDRFVKG TCPKCKAEDQ YGDSCEVCGA TYDPTELINP RSVISGQSPI
190 200 210 220 230 240
QKNSEHFFFD LPALEKNIKD WIESNTLLQP EVANKLAEWF EQGLQSWDIS RDAPYFGFAI
250 260 270 280 290 300
PGTNEQKFFY VWLDAPMGYI ASFKDYCNRN EIDFDDFWGD NSESELYHFI GKDIIYFHAL
310 320 330 340 350 360
FWPAILSSTG YKTPTSVFAN GFLTVNGKKM SKSRGTFIQA RTYLDNLEPS YLRYYFASRL
370 380 390 400 410 420
TSRIDDIDLN LEEFVTKSNS DIVGKVVNIA SRCAGFIYKK FDATLSGEIF DPELESEFSK
430 440 450 460 470 480
NHDAITQAFE KREFAHAVRL IMALADKANQ FIDYHKPWQL AKEEGQEQKV HQVCSQGINM
490 500 510 520 530 540
FKVLIAYLKP IIPSIVAEAE RFLNIQFISW ADAPKFLINH KIDKFKPLAT RIEKEKVDKI
550 560 570 580 590 600
LEDTKKMLEN EQAPQSKKEE PKLDITAECT FDDFMKVDLR IAKITEASHV EGADKLLKLI
610 620 630 640 650 660
LDLGGVTKQV FAGIKSAYKP EDLIGKHTVM VANLAPRKMK FGMSEGMVLA AGDGKGIYIL
670
EPHEGAQPGM RVK